Asian-Pacific consensus statement on the management of chronic hepatitis B: A 2012 update

Liaw, Yun-Fan, Kao, Jia-Horng, Piratvisuth, Teerha, Chan, Henry Lik Yuen, Chien, Rong-Nan, Liu, Chun-Jen, Gane, Ed, Locarnini, Stephen, Lim, Seng-Gee, Han, Kwang-Hyub, Amarapurkar, Deepak, Cooksley, Graham, Jafri, Wasim, Mohamed, Rosmawati, Hou, Jin-Lin, Chuang, Wan-Long, Lesmana, Laurentius A., Sollano, Jose D., Suh, Dong-Jin and Omata, Masao (2012) Asian-Pacific consensus statement on the management of chronic hepatitis B: A 2012 update. Hepatology International, 6 3: 531-561. doi:10.1007/s12072-012-9365-4

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Author Liaw, Yun-Fan
Kao, Jia-Horng
Piratvisuth, Teerha
Chan, Henry Lik Yuen
Chien, Rong-Nan
Liu, Chun-Jen
Gane, Ed
Locarnini, Stephen
Lim, Seng-Gee
Han, Kwang-Hyub
Amarapurkar, Deepak
Cooksley, Graham
Jafri, Wasim
Mohamed, Rosmawati
Hou, Jin-Lin
Chuang, Wan-Long
Lesmana, Laurentius A.
Sollano, Jose D.
Suh, Dong-Jin
Omata, Masao
Title Asian-Pacific consensus statement on the management of chronic hepatitis B: A 2012 update
Journal name Hepatology International   Check publisher's open access policy
ISSN 1936-0533
Publication date 2012-06
Sub-type Article (original research)
DOI 10.1007/s12072-012-9365-4
Volume 6
Issue 3
Start page 531
End page 561
Total pages 31
Place of publication New Delhi, India
Publisher Springer (India)
Collection year 2013
Language eng
Abstract Large volume of new data on the natural history and treatment of chronic hepatitis B virus (HBV) infection have become available since 2008. These include further studies in asymptomatic subjects with chronic HBV infection and community-based cohorts, the role of HBV genotype/naturally occurring HBV mutations, the application of non-invasive assessment of hepatic fibrosis and quantitation of HBV surface antigen and new drug or new strategies towards more effective therapy. To update HBV management guidelines, relevant new data were reviewed and assessed by experts from the region, and the significance of the reported findings was discussed and debated. The earlier "Asian-Pacific consensus statement on the management of chronic hepatitis B" was revised accordingly. The key terms used in the statement were also defined. The new guidelines include general management, indications for fibrosis assessment, time to start or stop drug therapy, choice of drug to initiate therapy, when and how to monitor the patients during and after stopping drug therapy. Recommendations on the therapy of patients in special circumstances, including women in childbearing age, patients with antiviral drug resistance, concurrent viral infection, hepatic decompensation, patients receiving immune suppression or chemotherapy and patients in the setting of liver transplantation and hepatocellular carcinoma, are also included.
Keyword Chronic hepatitis B
Liver cirrhosis
Hepatocellular carcinoma
Hepatitis B virus (HBV)
Pegylated interferon
Positive chronic hepatitis
E-antigen seroconversion
Tenofovir disoproxil fumarate
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Published online: 17 May 2012.

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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