Adolescent impulsivity phenotypes characterized by distinct brain networks

Whelan, Robert, Conrod, Patricia J., Poline, Jean-Baptiste, Lourdusamy, Anbarasu, Banaschewski, Tobias, Barker, Gareth J., Bellgrove, Mark A., Büchel, Christian, Byrne, Mark, Cummins, Tarrant D. R., Fauth-Buhler, Mira, Flor, Herta, Gallinat, Jürgen, Heinz, Andreas, Ittermann, Bernd, Mann, Karl, Martinot, Jean-Luc, Lalor, Edmund C., Lathrop, Mark, Loth, Eva, Nees, Frauke, Paus, Tomas, Rietschel, Marcella, Smolka, Michael N., Spanagel, Rainer, Stephens, David N., Struve, Maren, Thyreau, Benjamin, Vollstaedt-Klein, Sabine, Robbins, Trevor W., Schumann, Gunter, Garavan, Hugh and IMAGEN Consortium (2012) Adolescent impulsivity phenotypes characterized by distinct brain networks. Nature Neuroscience, 15 6: 920-925.


Author Whelan, Robert
Conrod, Patricia J.
Poline, Jean-Baptiste
Lourdusamy, Anbarasu
Banaschewski, Tobias
Barker, Gareth J.
Bellgrove, Mark A.
Büchel, Christian
Byrne, Mark
Cummins, Tarrant D. R.
Fauth-Buhler, Mira
Flor, Herta
Gallinat, Jürgen
Heinz, Andreas
Ittermann, Bernd
Mann, Karl
Martinot, Jean-Luc
Lalor, Edmund C.
Lathrop, Mark
Loth, Eva
Nees, Frauke
Paus, Tomas
Rietschel, Marcella
Smolka, Michael N.
Spanagel, Rainer
Stephens, David N.
Struve, Maren
Thyreau, Benjamin
Vollstaedt-Klein, Sabine
Robbins, Trevor W.
Schumann, Gunter
Garavan, Hugh
IMAGEN Consortium
Total Author Count Override 32
Title Adolescent impulsivity phenotypes characterized by distinct brain networks
Journal name Nature Neuroscience  (ERA 2012 Listed)    (ERA 2010 Rank A*)   Check publisher's open access policy
Publication date 2012-06
Sub-type Article
DOI 10.1038/nn.3092
Volume number 15
Issue number 6
ISSN 1097-6256; 1546-1726
Start page 920
End page 925
Total pages 6
Place of publication New York, United States
Publisher Nature Publishing
Collection year 2013
Language eng
Abstract The impulsive behavior that is often characteristic of adolescence may reflect underlying neurodevelopmental processes. Moreover, impulsivity is a multi-dimensional construct, and it is plausible that distinct brain networks contribute to its different cognitive, clinical and behavioral aspects. As these networks have not yet been described, we identified distinct cortical and subcortical networks underlying successful inhibitions and inhibition failures in a large sample (n = 1,896) of 14-year-old adolescents. Different networks were associated with drug use (n = 1,593) and attention-deficit hyperactivity. disorder symptoms (n = 342). Hypofunctioning of a specific orbitofrontal cortical network was associated with likelihood of initiating drug use in early adolescence. Right inferior frontal activity was related to the speed of the inhibition process (n = 826) and use of illegal substances and associated with genetic variation in a norepinephrine transporter gene (n = 819). Our results indicate that both neural endophenotypes and genetic variation give rise to the various manifestations of impulsive behavior
Keyword Response-inhibition
Drug-addiction
Individual-differences
Orbitofrontal cortex
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article
Collections: Queensland Brain Institute Publications
Official 2013 Collection
 
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