Effects of crosslink density on hydrolytic degradation of poly(L-lactide)-based networks

George, Karina A., Chirila, Traian V. and Wentrup-Byrne, Edeline (2012) Effects of crosslink density on hydrolytic degradation of poly(L-lactide)-based networks. Polymer Degradation and Stability, 97 6: 964-971. doi:10.1016/j.polymdegradstab.2012.03.017

Author George, Karina A.
Chirila, Traian V.
Wentrup-Byrne, Edeline
Title Effects of crosslink density on hydrolytic degradation of poly(L-lactide)-based networks
Journal name Polymer Degradation and Stability   Check publisher's open access policy
ISSN 0141-3910
Publication date 2012-06
Sub-type Article (original research)
DOI 10.1016/j.polymdegradstab.2012.03.017
Volume 97
Issue 6
Start page 964
End page 971
Total pages 8
Place of publication London, United Kingdom
Publisher Elsevier
Collection year 2013
Language eng
Formatted abstract
We have studied the accelerated degradation of three crosslinked poly(l-lactide) (PLLA) networks in 0.1 M NaOH at 37°C. It was found that the degradation rate depends strongly on the molecular weight between crosslinks (M c). Compared to a linear PLLA reference sample, all networks displayed much slower mass loss. A clear relationship was found to exist between the rate of mass loss, swelling and M c. The network with the greatest M c (3500 g/mol), underwent the fastest mass loss throughout the 4 week study, while the networks with the smallest M c (1400 g/mol) showed very slow mass loss, with only 28% loss after 4 weeks. SEM images of degraded samples clearly showed that degradation only occurred close to the surface in the sample where the M c was 1400 g/mol. However, results also showed that with increasing M c the degradation occurred further into the bulk of the network. The linear PLLA sample appeared to hydrolysis homogeneously. 1H NMR analysis of the soluble degradation products revealed that when the M c was 1400 g/mol, the succinate groups were released from the networks preferentially to the pentaerythritol groups. The delayed release of pentaerythritol suggests that the degradation products of the star prepolymer cores are trapped within the matrix for longer than the degradation products produced from other regions of the network.
Keyword Polylactide
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 19 March 2012.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Medicine Publications
Australian Institute for Bioengineering and Nanotechnology Publications
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