Folding pentapeptides into left and right handed alpha helices

Hoang, Huy N., Abbenante, Giovanni, Hill, Timothy A., Ruiz-Gomez, Gloria and Fairlie, David P. (2012) Folding pentapeptides into left and right handed alpha helices. Tetrahedron, 68 23: 4513-4516. doi:10.1016/j.tet.2011.10.108

Author Hoang, Huy N.
Abbenante, Giovanni
Hill, Timothy A.
Ruiz-Gomez, Gloria
Fairlie, David P.
Title Folding pentapeptides into left and right handed alpha helices
Journal name Tetrahedron   Check publisher's open access policy
ISSN 0040-4020
Publication date 2012-06
Year available 2011
Sub-type Article (original research)
DOI 10.1016/j.tet.2011.10.108
Volume 68
Issue 23
Start page 4513
End page 4516
Total pages 4
Place of publication Oxford United Kingdom
Publisher Pergamon
Collection year 2013
Language eng
Abstract Left or right handed alpha helicity can be induced in a pentapeptide (ANGYG) by appending left or right handed helical cycles as chiral templates. This sequence corresponds to a rare left handed helix found in the protein alanine racemase. Circular dichroism spectra reveal that pentapeptide ANGYG has no detectable structure in aq phosphate buffer, that it is an ambidextrous peptide in that it can be directed to fold into either a left handed or right handed alpha helix in water, with greater propensity for the uncommon left handed than the normal right handed conformation. A helix-inducing cyclic peptide at both ends of this peptide was more effective at inducing alpha helicity than a single cyclic peptide at one end. The alpha helical cyclic peptides provide novel tools for folding short peptides into thermodynamically unstable helices in water, and for studying factors that control chirality and helix induction.
Keyword Left handed helix
Helical inducer
Alpha helix
Circular dichroism
Side-Chain Chirality
Protein Structures
Ambidextrous Helices
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online: 6 November 2011.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
Institute for Molecular Bioscience - Publications
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