Liposaccharide-based nanoparticulate drug delivery system

Abdelrahim, Adel S., Simerska, Pavla and Toth, Istvan (2012) Liposaccharide-based nanoparticulate drug delivery system. Tetrahedron, 68 25: 4967-4975. doi:10.1016/j.tet.2012.04.064

Author Abdelrahim, Adel S.
Simerska, Pavla
Toth, Istvan
Title Liposaccharide-based nanoparticulate drug delivery system
Journal name Tetrahedron   Check publisher's open access policy
ISSN 0040-4020
Publication date 2012-06-24
Sub-type Article (original research)
DOI 10.1016/j.tet.2012.04.064
Volume 68
Issue 25
Start page 4967
End page 4975
Total pages 9
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon
Collection year 2013
Language eng
Abstract A series of anionic liposaccharide derivatives were synthesized in order to develop a system, which would have the capacity to act as an absorption enhancer and to improve oral bioavailability of drugs. The addition of a liposaccharide to a drug enhances drug stability against enzymatic degradation, while the lipophilicity can be controlled by variation of the lipid side chain. All liposaccharide derivatives were purified and fully characterized by nuclear magnetic resonance and high-resolution mass spectrometry. The thermodynamic profiles, critical aggregation concentrations and size of the synthesized liposaccharides were determined by isothermal titration microcalorimetry, transmission electron microscopy and dynamic light scattering. These liposaccharides formed nanoparticles with sizes below 100 nm.
Keyword Charged liposaccharide
Absorption enhancer
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Chemistry and Molecular Biosciences
School of Pharmacy Publications
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Citation counts: TR Web of Science Citation Count  Cited 2 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 2 times in Scopus Article | Citations
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Created: Wed, 20 Jun 2012, 12:01:25 EST by Professor Istvan Toth on behalf of School of Pharmacy