Caffeine attenuates metabolic syndrome in diet-induced obese rats

Panchal, Sunil K., Wong, Weng-Yew, Kauter, Kate, Ward, Leigh C. and Brown, Lindsay (2012) Caffeine attenuates metabolic syndrome in diet-induced obese rats. Nutrition, 28 10: 1055-1062. doi:10.1016/j.nut.2012.02.013

Author Panchal, Sunil K.
Wong, Weng-Yew
Kauter, Kate
Ward, Leigh C.
Brown, Lindsay
Title Caffeine attenuates metabolic syndrome in diet-induced obese rats
Journal name Nutrition   Check publisher's open access policy
ISSN 0899-9007
Publication date 2012
Sub-type Article (original research)
DOI 10.1016/j.nut.2012.02.013
Volume 28
Issue 10
Start page 1055
End page 1062
Total pages 8
Place of publication New York, United States
Publisher Elsevier
Collection year 2013
Language eng
Formatted abstract
Objective: Caffeine is a constituent of many non-alcoholic beverages. Pharmacological actions of caffeine include the antagonism of adenosine receptors and the inhibition of phosphodiesterase activity. The A1 adenosine receptors present on adipocytes are involved in the control of fatty acid uptake and lipolysis. In this study, the effects of caffeine were characterized in a diet-induced metabolic syndrome in rats.
Methods: Rats were given a high-carbohydrate, high-fat diet (mainly containing fructose and beef tallow) for 16 wk. The control rats were given a corn starch diet. Treatment groups were given caffeine 0.5 g/kg of food for the last 8 wk of the 16-wk protocol. The structure and function of the heart and the liver were investigated in addition to the metabolic parameters including the plasma lipid components.
Results: The high-carbohydrate, high-fat diet induced symptoms of metabolic syndrome, including obesity, dyslipidemia, impaired glucose tolerance, decreased insulin sensitivity, and increased systolic blood pressure, associated with the development of cardiovascular remodeling and non-alcoholic steatohepatitis. The treatment with caffeine in the rats fed the high-carbohydrate, high-fat diet decreased body fat and systolic blood pressure, improved glucose tolerance and insulin sensitivity, and attenuated cardiovascular and hepatic abnormalities, although the plasma lipid concentrations were further increased.
Conclusion: Decreased total body fat, concurrent with increased plasma lipid concentrations, reflects the lipolytic effects of caffeine in adipocytes, likely owing to the caffeine antagonism of A1 adenosine receptors on adipocytes.
Keyword Adenosine receptor
Cardiovascular remodeling
Metabolic syndrome
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 19 June 2012

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Biomedical Sciences Publications
School of Chemistry and Molecular Biosciences
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Created: Wed, 20 Jun 2012, 08:32:45 EST by Lucy O'Brien on behalf of School of Chemistry & Molecular Biosciences