Diffusion MRI of the neonate brain: acquisition, processing and analysis techniques

Pannek, Kerstin, Guzzetta, Andrea, Colditz, Paul and Rose, Stephen E. (2012) Diffusion MRI of the neonate brain: acquisition, processing and analysis techniques. Pediatric Radiology, 42 10: 1169-1182. doi:10.1007/s00247-012-2427-x


Author Pannek, Kerstin
Guzzetta, Andrea
Colditz, Paul
Rose, Stephen E.
Title Diffusion MRI of the neonate brain: acquisition, processing and analysis techniques
Journal name Pediatric Radiology   Check publisher's open access policy
ISSN 0301-0449
1432-1998
Publication date 2012-10-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1007/s00247-012-2427-x
Volume 42
Issue 10
Start page 1169
End page 1182
Total pages 14
Place of publication Heidelberg, Germany
Publisher Springer
Collection year 2013
Language eng
Abstract Diffusion MRI (dMRI) is a popular noninvasive imaging modality for the investigation of the neonate brain. It enables the assessment of white matter integrity, and is particularly suited for studying white matter maturation in the preterm and term neonate brain. Diffusion tractography allows the delineation of white matter pathways and assessment of connectivity in vivo. In this review, we address the challenges of performing and analysing neonate dMRI. Of particular importance in dMRI analysis is adequate data preprocessing to reduce image distortions inherent to the acquisition technique, as well as artefacts caused by head movement. We present a summary of techniques that should be used in the preprocessing of neonate dMRI data, and demonstrate the effect of these important correction steps. Furthermore, we give an overview of available analysis techniques, ranging from voxel-based analysis of anisotropy metrics including tract-based spatial statistics (TBSS) to recently developed methods of statistical analysis addressing issues of resolving complex white matter architecture. We highlight the importance of resolving crossing fibres for tractography and outline several tractography-based techniques, including connectivity-based segmentation, the connectome and tractography mapping. These techniques provide powerful tools for the investigation of brain development and maturation.
Keyword Diffusion MRI
Neonate
Tractography
Voxel-based analysis
Q-Index Code CX
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published Online First 18 August 2012

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: UQ Centre for Clinical Research Publications
Non HERDC
ERA White List Items
School of Medicine Publications
Centre for Advanced Imaging Publications
 
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Created: Thu, 14 Jun 2012, 20:54:41 EST by Miss Kerstin Pannek on behalf of School of Medicine