Cancer risks for relatives of patients with serrated polyposis

Win, Aung Ko, Walters, Rhiannon J., Buchanan, Daniel D., Jenkins, Mark A., Sweet, Kevin, Frankel, Wendy L., de la Chapelle, Albert, McKeone, Diane M., Walsh, Michael D., Clendenning, Mark, Pearson, Sally-Ann, Pavluk, Erika, Nagler, Belinda, Hopper, John L., Gattas, Michael R., Goldblatt, Jack, George, Jill, Suthers, Graeme K., Phillips, Kerry D., Woodall, Sonja, Arnold, Julie, Tucker, Kathy, Field, Michael, Greening, Sian, Gallinger, Steve, Aronson, Melyssa, Perrier, Renee, Woods, Michael O., Green, Jane S., Walker, Neal, Rosty, Christophe, Parry, Susan and Young, Joanne P. (2012) Cancer risks for relatives of patients with serrated polyposis. American Journal of Gastroenterology, 107 5: 770-778. doi:10.1038/ajg.2012.52

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Author Win, Aung Ko
Walters, Rhiannon J.
Buchanan, Daniel D.
Jenkins, Mark A.
Sweet, Kevin
Frankel, Wendy L.
de la Chapelle, Albert
McKeone, Diane M.
Walsh, Michael D.
Clendenning, Mark
Pearson, Sally-Ann
Pavluk, Erika
Nagler, Belinda
Hopper, John L.
Gattas, Michael R.
Goldblatt, Jack
George, Jill
Suthers, Graeme K.
Phillips, Kerry D.
Woodall, Sonja
Arnold, Julie
Tucker, Kathy
Field, Michael
Greening, Sian
Gallinger, Steve
Aronson, Melyssa
Perrier, Renee
Woods, Michael O.
Green, Jane S.
Walker, Neal
Rosty, Christophe
Parry, Susan
Young, Joanne P.
Title Cancer risks for relatives of patients with serrated polyposis
Journal name American Journal of Gastroenterology   Check publisher's open access policy
ISSN 0002-9270
Publication date 2012-05
Sub-type Article (original research)
DOI 10.1038/ajg.2012.52
Open Access Status File (Author Post-print)
Volume 107
Issue 5
Start page 770
End page 778
Total pages 9
Place of publication New York United States
Publisher Nature Publishing Group
Collection year 2013
Language eng
Formatted abstract
OBJECTIVES:Serrated polyposis (hyperplastic polyposis) is characterized by multiple polyps with serrated architecture in the colorectum. Although patients with serrated polyposis are known to be at increased risk of colorectal cancer (CRC) and possibly extracolonic cancers, cancer risk for their relatives has not been widely explored. The aim of this study was to estimate the risks of CRC and extracolonic cancers for relatives of patients with serrated polyposis.

METHODS:A cohort of the 1,639 first- and second-degree relatives of 100 index patients with serrated polyposis recruited regardless of a family history of polyps or cancer from genetic clinics in Australia, New Zealand, Canada, and the USA, were retrospectively analyzed to estimate the country-, age-, and sex-specific standardized incidence ratios (SIRs) for relatives compared with the general population.RESULTS:A total of 102 CRCs were observed in first- and second-relatives (SIR 2.25, 95% confidence interval (CI) 1.75-2.93; P<0.001), with 54 in first-degree relatives (SIR 5.16, 95% CI 3.70-7.30; P<0.001) and 48 in second-degree relatives (SIR 1.38, 95% CI 1.01-1.91; P=0.04). Six pancreatic cancers were observed in first-degree relatives (SIR 3.64, 95% CI 1.70-9.21; P=0.003). There was no statistical evidence of increased risk for cancer of the stomach, brain, breast, or prostate.

CONCLUSIONS:Our finding that relatives of serrated polyposis patients are at significantly increased risk of colorectal and pancreatic cancer adds to the accumulating evidence that serrated polyposis has an inherited component.
Keyword Colorectal-Cancer
Hyperplastic Polyposis
1st-Degree Relatives
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Advance online publication: 24 April 2012.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Medicine Publications
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