A pH-responsive drug delivery system based on chitosan coated mesoporous silica nanoparticles

Popat, Amirali, Liu, Jian, Lu, Gao Qing (Max) and Qiao, Shi Zhang (2012) A pH-responsive drug delivery system based on chitosan coated mesoporous silica nanoparticles. Journal of Materials Chemistry, 22 22: 11173-11178. doi:10.1039/c2jm30501a


Author Popat, Amirali
Liu, Jian
Lu, Gao Qing (Max)
Qiao, Shi Zhang
Title A pH-responsive drug delivery system based on chitosan coated mesoporous silica nanoparticles
Journal name Journal of Materials Chemistry   Check publisher's open access policy
ISSN 0959-9428
1364-5501
Publication date 2012
Sub-type Article (original research)
DOI 10.1039/c2jm30501a
Volume 22
Issue 22
Start page 11173
End page 11178
Total pages 6
Place of publication Cambridge, United Kingdom
Publisher Royal Society of Chemistry
Collection year 2013
Language eng
Abstract Herein, we report a core–shell pH-responsive drug-carrier based on chitosan-coated mesoporous silica nanospheres. The efficient positively charged polymer (chitosan) coating is realized by the phosphoramidate covalent bonding between phosphonate groups on the surface of the mesoporous silica nanoparticles (MSNs) and amino groups on chitosan. A pH-responsive release of ibuprofen has been achieved by varying the shell structure of positively charged chitosan in the designed pH 4.0–7.4 solution. Under basic conditions, chitosan forms a gel like structure which is insoluble and hence prevents ibuprofen release at pH 7.4. When the pH is below its PI (6.3), the drug has been released due to protonation of the amino group on chitosan. These results imply that the chitosan coated-MSNs are promising platforms to construct pH-responsive controlled drug delivery systems.
Keyword Core-shell structure
Guest molecules
Release
Immobilization
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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