Wzy-dependent bacterial capsules as potential drug targets

Ericsson, Daniel J., Standish, Alistair, Kobe, Bostjan and Morona, Renata (2012) Wzy-dependent bacterial capsules as potential drug targets. Current Drug Targets, 13 11: 1421-1431. doi:10.2174/138945012803530279

Author Ericsson, Daniel J.
Standish, Alistair
Kobe, Bostjan
Morona, Renata
Title Wzy-dependent bacterial capsules as potential drug targets
Journal name Current Drug Targets   Check publisher's open access policy
ISSN 1389-4501
Publication date 2012-10
Sub-type Article (original research)
DOI 10.2174/138945012803530279
Open Access Status
Volume 13
Issue 11
Start page 1421
End page 1431
Total pages 11
Place of publication Bussum, The Netherlands
Publisher Bentham Science Publishers
Collection year 2013
Language eng
Formatted abstract
The bacterial capsule is a recognized virulence factor in pathogenic bacteria. It likely works as an anti-phagocytic barrier by minimizing complement deposition on the bacterial surface. With the continual rise of bacterial pathogens resistant to multiple antibiotics, there is an increasing need for novel drugs. In the Wzy-dependent pathway, the biosynthesis of capsular polysaccharide (CPS) is regulated by a phosphoregulatory system, whose main components consist of bacterial-tyrosine kinases (BY-kinases) and their cognate phosphatases. The ability to regulate capsule biosynthesis has been shown to be vital for pathogenicity, because different stages of infection require a shift in capsule thickness, making the phosphoregulatory proteins suitable as drug targets. Here, we review the role of regulatory proteins focusing on Streptococcus pneumoniae, Staphylococcus aureus, and Escherichia coli and discuss their suitability as targets in structure-based drug design.
Keyword Antibiotic resistance
Bacterial pathogens
Drug discovery
Protein tyrosine kinase
Protein tyrosine phosphatase
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Chemistry and Molecular Biosciences
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Citation counts: TR Web of Science Citation Count  Cited 6 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 6 times in Scopus Article | Citations
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Created: Thu, 07 Jun 2012, 09:09:25 EST by Lucy O'Brien on behalf of School of Chemistry & Molecular Biosciences