Wzy-dependent bacterial capsules as potential drug targets

Ericsson, Daniel J., Standish, Alistair, Kobe, Bostjan and Morona, Renata (2012) Wzy-dependent bacterial capsules as potential drug targets. Current Drug Targets, 13 11: 1421-1431.


Author Ericsson, Daniel J.
Standish, Alistair
Kobe, Bostjan
Morona, Renata
Title Wzy-dependent bacterial capsules as potential drug targets
Journal name Current Drug Targets  (ERA 2012 Listed)    (ERA 2010 Rank B)   Check publisher's open access policy
Publication date 2012-10
Sub-type Article
DOI 10.2174/138945012803530279
Volume number 13
Issue number 11
ISSN 1389-4501
1873-5592
Start page 1421
End page 1431
Total pages 11
Place of publication Bussum, The Netherlands
Publisher Bentham Science Publishers
Collection year 2013
Language eng
Formatted abstract The bacterial capsule is a recognized virulence factor in pathogenic bacteria. It likely works as an anti-phagocytic barrier by minimizing complement deposition on the bacterial surface. With the continual rise of bacterial pathogens resistant to multiple antibiotics, there is an increasing need for novel drugs. In the Wzy-dependent pathway, the biosynthesis of capsular polysaccharide (CPS) is regulated by a phosphoregulatory system, whose main components consist of bacterial-tyrosine kinases (BY-kinases) and their cognate phosphatases. The ability to regulate capsule biosynthesis has been shown to be vital for pathogenicity, because different stages of infection require a shift in capsule thickness, making the phosphoregulatory proteins suitable as drug targets. Here, we review the role of regulatory proteins focusing on Streptococcus pneumoniae, Staphylococcus aureus, and Escherichia coli and discuss their suitability as targets in structure-based drug design.
Keyword Antibiotic resistance
Bacterial pathogens
Capsule
Drug discovery
Protein tyrosine kinase
Protein tyrosine phosphatase
Wzy
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article
Collections: Official 2013 Collection
School of Chemistry and Molecular Biosciences
 
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Created: Thu, 07 Jun 2012, 09:09:25 EST by Lucy O'Brien on behalf of School of Chemistry & Molecular Biosciences