Five-year longitudinal assessment of the downstream impact on schistosomiasis transmission following closure of the Three Gorges Dam

Gray, Darren J., Thrift, Aaron P., Williams, Gail M., Zheng, Feng, Li, Yue-Sheng, Guo, Jiagang, Chen, Honggen, Wang, Tianping, Xu, Xin Jiang, Zhu, Rong, Zhu, Hongqing, Cao, Chun Li, Lin, Dan Dan, Zhao, Zhen Yuan, Li, Robert S., Davis, George M. and McManus, Donald P. (2012) Five-year longitudinal assessment of the downstream impact on schistosomiasis transmission following closure of the Three Gorges Dam. Plos Neglected Tropical Diseases, 6 4: e1588-1-e1588-9. doi:10.1371/journal.pntd.0001588

Author Gray, Darren J.
Thrift, Aaron P.
Williams, Gail M.
Zheng, Feng
Li, Yue-Sheng
Guo, Jiagang
Chen, Honggen
Wang, Tianping
Xu, Xin Jiang
Zhu, Rong
Zhu, Hongqing
Cao, Chun Li
Lin, Dan Dan
Zhao, Zhen Yuan
Li, Robert S.
Davis, George M.
McManus, Donald P.
Total Author Count Override 17
Title Five-year longitudinal assessment of the downstream impact on schistosomiasis transmission following closure of the Three Gorges Dam
Journal name Plos Neglected Tropical Diseases   Check publisher's open access policy
ISSN 1935-2735
Publication date 2012-04
Sub-type Article (original research)
DOI 10.1371/journal.pntd.0001588
Open Access Status DOI
Volume 6
Issue 4
Start page e1588-1
End page e1588-9
Total pages 9
Place of publication San Francisco, CA, United States
Publisher Public Library of Science
Collection year 2013
Language eng
Formatted abstract
Schistosoma japonicum is a major public health concern in the Peoples' Republic of China (PRC), with about 800,000 people infected and another 50 million living in areas at risk of infection. Based on ecological, environmental, population genetic and molecular factors, schistosomiasis transmission in PRC can be categorised into four discrete ecosystems or transmission modes. It is predicted that, long-term, the Three Gorges Dam (TGD) will impact upon the transmission of schistosomiasis in the PRC, with varying degree across the four transmission modes.

Methodology/Principal Findings:
We undertook longitudinal surveillance from 2002 to 2006 in sentinel villages of the three transmission modes below the TGD across four provinces (Hunan, Jiangxi, Hubei and Anhui) to determine whether there was any immediate impact of the TGD on schistosomiasis transmission. Eight sentinel villages were selected to represent both province and transmission mode. The primary end point measured was human incidence. Here we present the results of this five-year longitudinal cohort study. Results showed that the incidence of human S. japonicum infection declined considerably within individual villages and overall mode over the course of the study. This is also reflected in the yearly odds ratios (adjusted) for infection risk that showed significant (P<0.01) downward trends in all modes over the follow-up period.

The decrease in human S. japonicum incidence observed across all transmission modes in this study can probably be attributed to the annual human and bovine PZQ chemotherapy. If an increase in schistosome transmission had occurred as a result of the TGD, it would be of negligible size compared to the treatment induced decline seen here. It appears therefore that there has been virtually no immediate impact of the TGD on schistosomiasis transmission downstream of the dam.
Keyword Republic-of-China
Poyang Lake
Japonicum Infection
Sichuan Province
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article number e1588

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Public Health Publications
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Citation counts: TR Web of Science Citation Count  Cited 15 times in Thomson Reuters Web of Science Article | Citations
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