A research agenda for Helminth diseases of humans: The problem of Helminthiases

Lustigman, Sara, Prichard, Roger K., Gazzinelli, Andrea, Grant, Warwick N., Boatin, Boakye A., McCarthy, James S. and Basanez, María-Gloria (2012) A research agenda for Helminth diseases of humans: The problem of Helminthiases. Plos Neglected Tropical Diseases, 6 4: e1582-1-e1582-13. doi:10.1371/journal.pntd.0001582


Author Lustigman, Sara
Prichard, Roger K.
Gazzinelli, Andrea
Grant, Warwick N.
Boatin, Boakye A.
McCarthy, James S.
Basanez, María-Gloria
Title A research agenda for Helminth diseases of humans: The problem of Helminthiases
Journal name Plos Neglected Tropical Diseases   Check publisher's open access policy
ISSN 1935-2735
1935-2735
Publication date 2012-04
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1371/journal.pntd.0001582
Open Access Status DOI
Volume 6
Issue 4
Start page e1582-1
End page e1582-13
Total pages 13
Place of publication San Francisco, CA, United States
Publisher Public Library of Science
Collection year 2013
Language eng
Abstract A disproportionate burden of helminthiases in human populations occurs in marginalised, low-income, and resource-constrained regions of the world, with over 1 billion people in developing areas of sub-Saharan Africa, Asia, and the Americas infected with one or more helminth species. The morbidity caused by such infections imposes a substantial burden of disease, contributing to a vicious circle of infection, poverty, decreased productivity, and inadequate socioeconomic development. Furthermore, helminth infection accentuates the morbidity of malaria and HIV/AIDS, and impairs vaccine efficacy. Polyparasitism is the norm in these populations, and infections tend to be persistent. Hence, there is a great need to reduce morbidity caused by helminth infections. However, major deficiencies exist in diagnostics and interventions, including vector control, drugs, and vaccines. Overcoming these deficiencies is hampered by major gaps in knowledge of helminth biology and transmission dynamics, platforms from which to help develop such tools. The Disease Reference Group on Helminths Infections (DRG4), established in 2009 by the Special Programme for Research and Training in Tropical Diseases (TDR), was given the mandate to review helminthiases research and identify research priorities and gaps. In this review, we provide an overview of the forces driving the persistence of helminthiases as a public health problem despite the many control initiatives that have been put in place; identify the main obstacles that impede progress towards their control and elimination; and discuss recent advances, opportunities, and challenges for the understanding of the biology, epidemiology, and control of these infections. The helminth infections that will be discussed include: onchocerciasis, lymphatic filariasis, soil-transmitted helminthiases, schistosomiasis, food-borne trematodiases, and taeniasis/cysticercosis.
Keyword Neglected Tropical Diseases
Eliminate Lymphatic Filariasis
Sub-Saharan Africa
Republic-of-Korea
Schistosoma-Japonicum
Rna Interference
Volvulus Transmission
Parasitic Nematodes
Cost-Effectiveness
Control Program
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article number e1582

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2013 Collection
School of Medicine Publications
 
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