A research agenda for Helminth diseases of humans: Intervention for control and elimination

Prichard, Roger K., Basanez, María-Gloria, Boatin, Boakye A., McCarthy, James S., Garcia, Héctor H., Yang, Guo-Jing, Sripa, Banchob and Lustigman, Sara (2012) A research agenda for Helminth diseases of humans: Intervention for control and elimination. Plos Neglected Tropical Diseases, 6 4: e1549-1-e1549-14. doi:10.1371/journal.pntd.0001549

Author Prichard, Roger K.
Basanez, María-Gloria
Boatin, Boakye A.
McCarthy, James S.
Garcia, Héctor H.
Yang, Guo-Jing
Sripa, Banchob
Lustigman, Sara
Title A research agenda for Helminth diseases of humans: Intervention for control and elimination
Journal name Plos Neglected Tropical Diseases   Check publisher's open access policy
ISSN 1935-2735
Publication date 2012-04
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1371/journal.pntd.0001549
Open Access Status DOI
Volume 6
Issue 4
Start page e1549-1
End page e1549-14
Total pages 14
Place of publication San Francisco, CA, United States
Publisher Public Library of Science
Collection year 2013
Language eng
Abstract Recognising the burden helminth infections impose on human populations, and particularly the poor, major intervention programmes have been launched to control onchocerciasis, lymphatic filariasis, soil-transmitted helminthiases, schistosomiasis, and cysticercosis. The Disease Reference Group on Helminth Infections (DRG4), established in 2009 by the Special Programme for Research and Training in Tropical Diseases (TDR), was given the mandate to review helminthiases research and identify research priorities and gaps. A summary of current helminth control initiatives is presented and available tools are described. Most of these programmes are highly dependent on mass drug administration (MDA) of anthelmintic drugs (donated or available at low cost) and require annual or biannual treatment of large numbers of at-risk populations, over prolonged periods of time. The continuation of prolonged MDA with a limited number of anthelmintics greatly increases the probability that drug resistance will develop, which would raise serious problems for continuation of control and the achievement of elimination. Most initiatives have focussed on a single type of helminth infection, but recognition of co-endemicity and polyparasitism is leading to more integration of control. An understanding of the implications of control integration for implementation, treatment coverage, combination of pharmaceuticals, and monitoring is needed. To achieve the goals of morbidity reduction or elimination of infection, novel tools need to be developed, including more efficacious drugs, vaccines, and/or antivectorial agents, new diagnostics for infection and assessment of drug efficacy, and markers for possible anthelmintic resistance. In addition, there is a need for the development of new formulations of some existing anthelmintics (e.g., paediatric formulations). To achieve ultimate elimination of helminth parasites, treatments for the above mentioned helminthiases, and for taeniasis and food-borne trematodiases, will need to be integrated with monitoring, education, sanitation, access to health services, and where appropriate, vector control or reduction of the parasite reservoir in alternative hosts. Based on an analysis of current knowledge gaps and identification of priorities, a research and development agenda for intervention tools considered necessary for control and elimination of human helminthiases is presented, and the challenges to be confronted are discussed.
Keyword Neglected Tropical Diseases
Onchocerca-Volvulus Transmission
Lymphatic Filariasis
Bancroftian Filariasis
Ivermectin Treatment
Vector Control
Macrocyclic Lactone
Control Program
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article number e1549

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2013 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 84 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 90 times in Scopus Article | Citations
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Created: Tue, 05 Jun 2012, 03:03:48 EST by System User