A research agenda for Helminth diseases of humans: Towards control and elimination

Boatin, Boakye A., Basanez, María-Gloria, Prichard, Roger K., Awadzi, Kwablah, Barakat, Rashida M., Garcia, Héctor H., Gazzinelli, Andrea, Grant, Warwick N., McCarthy, James S., N'Goran, Eliézer K., Osei-Atweneboana, Mike Y., Sripa, Banchob, Yang, Guo-Jing and Lustigman, Sara (2012) A research agenda for Helminth diseases of humans: Towards control and elimination. Plos Neglected Tropical Diseases, 6 4: e1547-1-e1547-10. doi:10.1371/journal.pntd.0001547

Author Boatin, Boakye A.
Basanez, María-Gloria
Prichard, Roger K.
Awadzi, Kwablah
Barakat, Rashida M.
Garcia, Héctor H.
Gazzinelli, Andrea
Grant, Warwick N.
McCarthy, James S.
N'Goran, Eliézer K.
Osei-Atweneboana, Mike Y.
Sripa, Banchob
Yang, Guo-Jing
Lustigman, Sara
Title A research agenda for Helminth diseases of humans: Towards control and elimination
Journal name Plos Neglected Tropical Diseases   Check publisher's open access policy
ISSN 1935-2735
Publication date 2012-04
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1371/journal.pntd.0001547
Open Access Status DOI
Volume 6
Issue 4
Start page e1547-1
End page e1547-10
Total pages 10
Place of publication San Francisco, CA, United States
Publisher Public Library of Science
Collection year 2013
Language eng
Abstract Human helminthiases are of considerable public health importance in sub-Saharan Africa, Asia, and Latin America. The acknowledgement of the disease burden due to helminth infections, the availability of donated or affordable drugs that are mostly safe and moderately efficacious, and the implementation of viable mass drug administration (MDA) interventions have prompted the establishment of various large-scale control and elimination programmes. These programmes have benefited from improved epidemiological mapping of the infections, better understanding of the scope and limitations of currently available diagnostics and of the relationship between infection and morbidity, feasibility of community-directed or school-based interventions, and advances in the design of monitoring and evaluation (M&E) protocols. Considerable success has been achieved in reducing morbidity or suppressing transmission in a number of settings, whilst challenges remain in many others. Some of the obstacles include the lack of diagnostic tools appropriate to the changing requirements of ongoing interventions and elimination settings; the reliance on a handful of drugs about which not enough is known regarding modes of action, modes of resistance, and optimal dosage singly or in combination; the difficulties in sustaining adequate coverage and compliance in prolonged and/or integrated programmes; an incomplete understanding of the social, behavioural, and environmental determinants of infection; and last, but not least, very little investment in research and development (R&D). The Disease Reference Group on Helminth Infections (DRG4), established in 2009 by the Special Programme for Research and Training in Tropical Diseases (TDR), was given the mandate to undertake a comprehensive review of recent advances in helminthiases research, identify research gaps, and rank priorities for an R&D agenda for the control and elimination of these infections. This review presents the processes undertaken to identify and rank ten top research priorities; discusses the implications of realising these priorities in terms of their potential for improving global health and achieving the Millennium Development Goals (MDGs); outlines salient research funding needs; and introduces the series of reviews that follow in this PLoS Neglected Tropical Diseases collection, "A Research Agenda for Helminth Diseases of Humans.".
Keyword Neglected Tropical Diseases
Soil-Transmitted Helminthiasis
Onchocerciasis Control Program
Lymphatic Filariasis
Bancroftian Filariasis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article number e1547

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2013 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 38 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 42 times in Scopus Article | Citations
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