Novel transcripts in the maxillary venom glands of advanced snakes

Fry, Bryan G., Scheib, Holger, de Azevedo, Inacio de L.M. Junqueira, Silva, Debora Andrade and Casewell, Nicholas R. (2012) Novel transcripts in the maxillary venom glands of advanced snakes. Toxicon, 59 7-8: 696-708. doi:10.1016/j.toxicon.2012.03.005

Author Fry, Bryan G.
Scheib, Holger
de Azevedo, Inacio de L.M. Junqueira
Silva, Debora Andrade
Casewell, Nicholas R.
Title Novel transcripts in the maxillary venom glands of advanced snakes
Journal name Toxicon   Check publisher's open access policy
ISSN 0041-0101
Publication date 2012-06
Sub-type Article (original research)
DOI 10.1016/j.toxicon.2012.03.005
Volume 59
Issue 7-8
Start page 696
End page 708
Total pages 13
Place of publication Oxford, United Kingdom
Publisher Pergamon
Collection year 2013
Language eng
Formatted abstract
Venom proteins are added to reptile venoms through duplication of a body protein gene, with the duplicate tissue-specifically expressed in the venom gland. Molecular scaffolds are recruited from a wide range of tissues and with a similar level of diversity of ancestral activity. Transcriptome studies have proven an effective and efficient tool for the discovery of novel toxin scaffolds. In this study, we applied venom gland transcriptomics to a wide taxonomical diversity of advanced snakes and recovered transcripts encoding three novel protein scaffold types lacking sequence homology to any previously characterised snake toxin type: lipocalin, phospholipase A 2 (type IIE) and vitelline membrane outer layer protein. In addition, the first snake maxillary venom gland isoforms were sequenced of ribonuclease, which was only recently sequenced from lizard mandibular venom glands. Further, novel isoforms were also recovered for the only recently characterised veficolin toxin class also shared between lizard and snake venoms. The additional complexity of snake venoms has important implications not only for understanding their molecular evolution, but also reinforces the tremendous importance of venoms as a diverse bio-resource.
Keyword Protein
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 20 March 2012.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Biological Sciences Publications
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