Viral infections and atopy in asthma pathogenesis: New rationales for asthma prevention and treatment

Holt, Patrick G. and Sly, Peter D. (2012) Viral infections and atopy in asthma pathogenesis: New rationales for asthma prevention and treatment. Nature Medicine, 18 5: 726-735.


Author Holt, Patrick G.
Sly, Peter D.
Title Viral infections and atopy in asthma pathogenesis: New rationales for asthma prevention and treatment
Journal name Nature Medicine  (ERA 2012 Listed)    (ERA 2010 Rank A*)   Check publisher's open access policy
Publication date 2012-05
Sub-type Review of research - research literature review (NOT book review
DOI 10.1038/nm.2768
Volume number 18
Issue number 5
ISSN 1078-8956; 1546-170X
Start page 726
End page 735
Total pages 10
Place of publication New York, United States
Publisher Nature Publishing Group
Collection year 2013
Language eng
Abstract Prospective birth cohort studies tracking asthma initiation and consolidation in community cohorts have identified viral infections occurring against a background of allergic sensitization to aeroallergens as a uniquely potent risk factor for the expression of acute severe asthma-like symptoms and for the ensuing development of asthma that can persist through childhood and into adulthood. A combination of recent experimental and human studies have suggested that underlying this bipartite process are a series of interactions between antiviral and atopic inflammatory pathways that are mediated by local activation of myeloid cell populations in the airway mucosa and the parallel programming and recruitment of their replacements from bone marrow. Targeting key components of these pathways at the appropriate stages of asthma provides new opportunities for the treatment of established asthma but, more crucially, for primary and secondary prevention of asthma during childhood.
Keyword Fc-Epsilon-R1
Respiratory syncytial virus
Plasmacytoid dendritic cells
House dust mite
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Review of research - research literature review (NOT book review
Collections: Faculty of Health Sciences -- Publications
Official 2013 Collection
Admin only - QCMRI
 
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