Viral infections and atopy in asthma pathogenesis: New rationales for asthma prevention and treatment

Holt, Patrick G. and Sly, Peter D. (2012) Viral infections and atopy in asthma pathogenesis: New rationales for asthma prevention and treatment. Nature Medicine, 18 5: 726-735.


Author Holt, Patrick G.
Sly, Peter D.
Title Viral infections and atopy in asthma pathogenesis: New rationales for asthma prevention and treatment
Journal name Nature Medicine   Check publisher's open access policy
ISSN 1078-8956
1546-170X
Publication date 2012-05
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/nm.2768
Volume 18
Issue 5
Start page 726
End page 735
Total pages 10
Place of publication New York, United States
Publisher Nature Publishing Group
Collection year 2013
Language eng
Abstract Prospective birth cohort studies tracking asthma initiation and consolidation in community cohorts have identified viral infections occurring against a background of allergic sensitization to aeroallergens as a uniquely potent risk factor for the expression of acute severe asthma-like symptoms and for the ensuing development of asthma that can persist through childhood and into adulthood. A combination of recent experimental and human studies have suggested that underlying this bipartite process are a series of interactions between antiviral and atopic inflammatory pathways that are mediated by local activation of myeloid cell populations in the airway mucosa and the parallel programming and recruitment of their replacements from bone marrow. Targeting key components of these pathways at the appropriate stages of asthma provides new opportunities for the treatment of established asthma but, more crucially, for primary and secondary prevention of asthma during childhood.
Keyword Fc-Epsilon-R1
Respiratory syncytial virus
Plasmacytoid dendritic cells
House dust mite
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Faculty of Health and Behavioural Sciences -- Publications
Official 2013 Collection
 
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