Selective diethylzinc reduction of imines in the presence of ketones catalyzed by Ni(acac) 2

Xiao, Xue, Wang, Haowei, Huang, Zhiyan, Yang, Jun, Bian, Xiaoxia and Qin, Yong (2006) Selective diethylzinc reduction of imines in the presence of ketones catalyzed by Ni(acac) 2. Organic Letters, 8 1: 139-142. doi:10.1021/ol052628q


Author Xiao, Xue
Wang, Haowei
Huang, Zhiyan
Yang, Jun
Bian, Xiaoxia
Qin, Yong
Title Selective diethylzinc reduction of imines in the presence of ketones catalyzed by Ni(acac) 2
Journal name Organic Letters   Check publisher's open access policy
ISSN 1523-7060
1523-7052
Publication date 2006-01
Sub-type Article (original research)
DOI 10.1021/ol052628q
Volume 8
Issue 1
Start page 139
End page 142
Total pages 4
Place of publication Washington, DC, United States
Publisher American Chemical Society
Language eng
Formatted abstract
A selective reduction method of an electronically deficient imine in the presence of ketone was developed by employing Et2Zn and 5 mol % of Ni(acac)2. The method was applied in the reduction of SS-tert-butanesulfinyl ketimines 1 to afford amines 2 in 23-92% yields and 73:27 to 98:2 diastereoselectivities. A plausible mechanism was proposed on the basis of an NMR study.
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
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Created: Mon, 04 Jun 2012, 14:58:49 EST by Sean Xiao on behalf of Institute for Molecular Bioscience