Molecular epidemiological study of Arctic rabies virus isolates from Greenland and comparison with isolates from throughout the Arctic and Baltic regions

Mansfield, K. L., Racloz, V., McElhinney, L. M., Marston, D. A., Johnson, N., Ronsholt, L., Christensen, L. S., Neuvonen, E., Botvinicin, A. D., Rupprecht, C. E. and Fooks, A. R. (2006) Molecular epidemiological study of Arctic rabies virus isolates from Greenland and comparison with isolates from throughout the Arctic and Baltic regions. Virus Research, 116 1-2: 1-10. doi:10.1016/j.virusres.2005.08.007


Author Mansfield, K. L.
Racloz, V.
McElhinney, L. M.
Marston, D. A.
Johnson, N.
Ronsholt, L.
Christensen, L. S.
Neuvonen, E.
Botvinicin, A. D.
Rupprecht, C. E.
Fooks, A. R.
Title Molecular epidemiological study of Arctic rabies virus isolates from Greenland and comparison with isolates from throughout the Arctic and Baltic regions
Journal name Virus Research   Check publisher's open access policy
ISSN 0168-1702
1872-7492
Publication date 2006-03
Sub-type Article (original research)
DOI 10.1016/j.virusres.2005.08.007
Volume 116
Issue 1-2
Start page 1
End page 10
Total pages 10
Place of publication Amsterdam, The Netherlands
Publisher Elsevier
Language eng
Formatted abstract
We report a molecular epidemiological study of rabies in Arctic countries by comparing a panel of novel Greenland isolates to a larger cohort of viral sequences from both Arctic and Baltic regions. Rabies virus isolates originating from wildlife (Arctic/red foxes, raccoon-dogs and reindeer), from domestic animals (dogs/cats) and from two human cases were investigated. The resulting 400 bp N-gene sequences were compared with isolates representing neighbouring Arctic or Baltic countries from North America, the former Soviet Union and Europe. Phylogenetic analysis demonstrated similarities between sequences from the Arctic and Arctic-like viruses, which were distinct from rabies isolates originating in the Baltic region of Europe, the Steppes in Russia and from North America. The Arctic-like group consist of isolates from India, Pakistan, southeast Siberia and Japan. The Arctic group was differentiated into two lineages, Arctic 1 and Arctic 2, with good bootstrap support. Arctic 1 is mainly comprised of Canadian isolates with a single fox isolate from Maine in the USA. Arctic 2 was further divided into sub-lineages: 2a/2b. Arctic 2a comprises isolates from the Arctic regions of Yakutia in northeast Siberia and Alaska. Arctic 2b isolates represent a biotype, which is dispersed throughout the Arctic region. The broad distribution of rabies in the Arctic regions including Greenland, Canada and Alaska provides evidence for the movement of rabies across borders.
Keyword Rabics
Greenland
Arctic
Baltic
Zoonosis
Wildlife
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Veterinary Science Publications
 
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Created: Thu, 31 May 2012, 09:51:33 EST by Vanessa Racloz on behalf of School of Veterinary Science