The elusive meningococcal meningitis serogroup: A systematic review of serogroup B epidemiology

Racloz, Vanessa N. and Luiz, Silva J. D (2010) The elusive meningococcal meningitis serogroup: A systematic review of serogroup B epidemiology. BMC Infectious Diseases, 10 175.1-175.9. doi:10.1186/1471-2334-10-175


Author Racloz, Vanessa N.
Luiz, Silva J. D
Title The elusive meningococcal meningitis serogroup: A systematic review of serogroup B epidemiology
Journal name BMC Infectious Diseases   Check publisher's open access policy
ISSN 1471-2334
Publication date 2010-06-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1186/1471-2334-10-175
Open Access Status DOI
Volume 10
Start page 175.1
End page 175.9
Total pages 9
Place of publication London, United Kingdom
Publisher BioMed Central
Language eng
Formatted abstract
Background: Invasive meningococcal disease (IMD), is a widely distributed, complex human disease affecting all age categories. The causative agent, Neisseria meningitidis, is spread through aerosol respiratory droplets. 13 different serogroups have been identified, each with varying epidemiological features including prevalence, virulence, immunogenicity, geographical and temporal distribution. Although preventative measures are available for several of the serogroups, meningococcal disease caused by serogroup B is of particular interest due to the challenge it presents concerning vaccine development.
Methods: A systematic review of peer reviewed studies and reports, the collection of data from national and international health resources, along with the analysis of the Multi Locus Sequence Typing database was carried out aimed at collecting information concerning serogroup B IMD and the epidemiology attached to it.
Results: A continuous output of related and novel STs occurring worldwide in terms of the hypervirulent clonal complexes was observed both in published studies and the MLST database in this case using the eburst software, which highlights the genetically diverse nature of serogroup B strains.
Conclusions: With the recent dominance of serogroup B IMD seen in many countries, along with the presence of antibiotic resistance, vaccine development needs to target areas of the bacterium which tackle this widespread and heterogeneous aspect of meningococcal meningitis disease.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Article # 175

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Public Health Publications
 
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Created: Thu, 31 May 2012, 19:32:20 EST by Vanessa Racloz on behalf of School of Public Health