Demonstration of late cardiotoxicity following bone marrow transplantation by assessment of exercise diastolic filling characteristics

Lele, S. S., Durrant, S. T. S., Atherton, J. J., Moore, T. D., Thomson, H. L., Khafagi, F. A. and Frenneaux, M. P. (1996) Demonstration of late cardiotoxicity following bone marrow transplantation by assessment of exercise diastolic filling characteristics. Bone Marrow Transplantation, 17 6: 1113-1118.

Author Lele, S. S.
Durrant, S. T. S.
Atherton, J. J.
Moore, T. D.
Thomson, H. L.
Khafagi, F. A.
Frenneaux, M. P.
Title Demonstration of late cardiotoxicity following bone marrow transplantation by assessment of exercise diastolic filling characteristics
Journal name Bone Marrow Transplantation   Check publisher's open access policy
ISSN 0268-3369
1476-5365
Publication date 1996-06
Sub-type Article (original research)
Volume 17
Issue 6
Start page 1113
End page 1118
Total pages 6
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Abstract We evaluated the role of rest and exercise left ventricular diastolic filling parameters as a marker of cardiotoxicity in 25 consecutive patients 1 year following BMT. Ten age- and sex-matched subjects served as controls. Patients were evaluated in toto and in three sub-groups according to chemotherapy, Left ventricular ejection fraction (EF), peak filling rate (PFR) and time to peak filling (TTPF) were assessed at rest and at peak exercise. EF and PPR were similar at rest and at peak exercise in patients and controls. TTPF was significantly prolonged at rest in patients compared to controls (200 ± 65 vs 131 ± 26 ms, P = 0.003) and at peak exercise was markedly longer in patients (142 ± 40 vs 54 ± 19 ms, P < 0.001). Sub-group analysis demonstrated abnormal resting TTPF in those patients who had received either combination anthracycline and CY or anthracycline and melphalan, while those patients who received CY alone had normal resting TTPF. However, exercise TTPF was abnormally prolonged in all patient groups. While all controls demonstrated a normal decrease in TTPF during exercise, four of the 25 patients had a paradoxical increase in TTPF during exercise. Exercise diastolic function may provide evidence of cardiotoxicity in long-term survivors of BMT.
Keyword Diastolic function
Cardiotoxicity
Chemotherapy
Bone marrow transplantation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Thu, 31 May 2012, 07:45:57 EST by Associate Professor John Atherton on behalf of Medicine - Royal Brisbane and Women's Hospital