TRPM7: A unique channel involved in magnesium homeostasis

Paravicini, Tamara M., Chubanov, Vladimir and Gudermann, Thomas (2012) TRPM7: A unique channel involved in magnesium homeostasis. The International Journal of Biochemistry and Cell Biology, 44 8: 1381-1384. doi:10.1016/j.biocel.2012.05.010

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Author Paravicini, Tamara M.
Chubanov, Vladimir
Gudermann, Thomas
Title TRPM7: A unique channel involved in magnesium homeostasis
Journal name The International Journal of Biochemistry and Cell Biology   Check publisher's open access policy
ISSN 0020-711X
1357-2725
1878-5875
Publication date 2012
Sub-type Article (original research)
DOI 10.1016/j.biocel.2012.05.010
Volume 44
Issue 8
Start page 1381
End page 1384
Total pages 4
Place of publication Oxford, United Kingdom
Publisher Pergamon
Collection year 2013
Language eng
Formatted abstract
TRPM7 is a ubiquitously expressed cation channel with a fused alpha kinase domain. It is highly permeable to magnesium and calcium, and is negatively gated by intracellular Mg2+ and Mg-ATP. Substrates for the TRPM7 kinase domain include annexinA1 and myosin IIA heavy chain, and there is evidence to suggest a functional interaction between the channel and kinase domains. Alterations in the expression and activity of TRPM7 have profound effects on cell proliferation and differentiation. Genetic deletion of TRPM7 in model systems demonstrates that this channel is critical for cellular growth and embryonic development. Here, we provide a brief overview of the activity of TRPM7 and the associated regulatory mechanisms. We will then discuss the biological functions of TRPM7, emphasizing its role in development and the potential pathophysiological significance of TRPM7 in neurological and cardiovascular disease.
Keyword TRPM7
Transient receptor potential
Magnesium
Alpha kinase
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online: 23 May 2012.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Biomedical Sciences Publications
 
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Created: Wed, 30 May 2012, 09:11:15 EST by Bacsweet Kaur on behalf of School of Biomedical Sciences