Is there a critical lesion site for unilateral spatial neglect? A meta-analysis using activation likelihood estimation

Molenberghs, Pascal, Sale, Martin V. and Mattingley, Jason B. (2012) Is there a critical lesion site for unilateral spatial neglect? A meta-analysis using activation likelihood estimation. Frontiers in Human Neuroscience, 6 APRIL 2012: 1-10. doi:10.3389/fnhum.2012.00078


Author Molenberghs, Pascal
Sale, Martin V.
Mattingley, Jason B.
Title Is there a critical lesion site for unilateral spatial neglect? A meta-analysis using activation likelihood estimation
Journal name Frontiers in Human Neuroscience   Check publisher's open access policy
ISSN 1662-5161
Publication date 2012-04
Sub-type Article (original research)
DOI 10.3389/fnhum.2012.00078
Open Access Status DOI
Volume 6
Issue APRIL 2012
Start page 1
End page 10
Total pages 10
Place of publication Lausanne, Switzerland
Publisher Frontiers Research Foundation
Collection year 2013
Language eng
Abstract The critical lesion site responsible for the syndrome of unilateral spatial neglect has been debated for more than a decade. Here we performed an activation likelihood estimation (ALE) to provide for the first time an objective quantitative index of the consistency of lesion sites across anatomical group studies of spatial neglect. The analysis revealed several distinct regions in which damage has consistently been associated with spatial neglect symptoms. Lesioned clusters were located in several cortical and subcortical regions of the right hemisphere, including the middle and superior temporal gyrus, inferior parietal lobule, intraparietal sulcus, precuneus, middle occipital gyrus, caudate nucleus and posterior insula, as well as in the white matter pathway corresponding to the posterior part of the superior longitudinal fasciculus. Further analyses suggested that separate lesion sites are associated with impairments in different behavioural tests, such as line bisection and target cancellation. Similarly, specific subcomponents of the heterogeneous neglect syndrome, such as extinction and allocentric and personal neglect, are associated with distinct lesion sites. Future progress in delineating the neuropathological correlates of spatial neglect will depend upon the development of more refined measures of perceptual and cognitive functions than those currently available in the clinical setting.
Keyword Unilateral spatial neglect
Extinction
Lesion mapping
ALE meta-analysis
Line bisection
Cancellation task
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online: 10 April 2012.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2013 Collection
School of Psychology Publications
 
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