Reconstitution of cutaneous neural immunological networks following bone marrow transplantation

Walsh, Laurence J., Athanasas-Platsis, Stavrosia and Savage, Neil W. (1996) Reconstitution of cutaneous neural immunological networks following bone marrow transplantation. Transplantation, 61 3: 413-417. doi:10.1097/00007890-199602150-00017

Author Walsh, Laurence J.
Athanasas-Platsis, Stavrosia
Savage, Neil W.
Title Reconstitution of cutaneous neural immunological networks following bone marrow transplantation
Journal name Transplantation   Check publisher's open access policy
ISSN 0041-1337
Publication date 1996-02
Year available 1996
Sub-type Article (original research)
DOI 10.1097/00007890-199602150-00017
Volume 61
Issue 3
Start page 413
End page 417
Total pages 5
Place of publication Philadelphia, PA United States
Publisher Lippincott Williams and Wilkins
Collection year 1997
Language eng
Formatted abstract
During allogeneic bone marrow transplantation (BMT), host epidermal Langerhans cells (LC) are depleted and replaced by LC derived from the bone marrow inoculum. LC have recently been shown to form intimate spatial associations with intraepithelial nerves (IEN), which release regulatory peptides. The present study investigated whether the IEN network within skin remains intact during BMT, and whether repopulating LC re-establish contacts with IEN. Double-labeling immunohistochemical techniques were employed using antibodies to CD1a and neural cell adhesion molecule (CD56) to identify LC and IEN, respectively. LC were depleted by conditioning for BMT, and repopulating LC reached normal values after day + 100. In contrast to fluctuations in the LC network, the frequency of IEN remained unchanged during the post-BMT period. Contacts between LC and IEN were present both before and after BMT, and repopulating LC established a spatial interaction with IEN similar to that seen before BMT. These data provide the first evidence for the dynamic nature of the spatial relationship of LC with IEN, and raise intriguing questions regarding the mechanisms that direct homing of LC within epithelia.
Keyword Epidermal Langerhans Cells
Antigen Expression
Dendritic Cells
Interleukin 1
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Dentistry Publications
School of Biomedical Sciences Publications
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