Genetic and biochemical characterization of a novel metallo-beta-lactamase, TMB-1, from an Achromobacter xylosoxidans strain isolated in Tripoli, Libya

EL Salabi, Allaaeddin, Borra, Pardha Saradhi, Toleman, Mark A., Samuelsen, Orjan and Walsh, Timothy R. (2012) Genetic and biochemical characterization of a novel metallo-beta-lactamase, TMB-1, from an Achromobacter xylosoxidans strain isolated in Tripoli, Libya. Antimicrobial Agents and Chemotherapy, 56 5: 2241-2245. doi:10.1128/AAC.05640-11

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Author EL Salabi, Allaaeddin
Borra, Pardha Saradhi
Toleman, Mark A.
Samuelsen, Orjan
Walsh, Timothy R.
Total Author Count Override 5
Title Genetic and biochemical characterization of a novel metallo-beta-lactamase, TMB-1, from an Achromobacter xylosoxidans strain isolated in Tripoli, Libya
Journal name Antimicrobial Agents and Chemotherapy   Check publisher's open access policy
ISSN 0066-4804
1098-6596
Publication date 2012-05
Year available 2012
Sub-type Article (original research)
DOI 10.1128/AAC.05640-11
Open Access Status File (Publisher version)
Volume 56
Issue 5
Start page 2241
End page 2245
Total pages 5
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Collection year 2013
Language eng
Formatted abstract
An Achromobacter xylosoxidans strain from the Tripoli central hospital produced a unique metallo-ß-lactamase, designated TMB-1, which is related to DIM-1 (62%) and GIM-1 (51%). blaTMB-1 was embedded in a class 1 integron and located on the chromosome.
The TMB-1 ß-lactamase has lower kcat values than both DIM-1 and GIM-1 with cephalosporins and carbapenems. The Km values were more similar to those of GIM-1 than those of DIM-1, with the overall kcat/Km values being lower than those for
GIM-1 and DIM-1.
Keyword Antimicrobial Surveillance Program
Class-1 Integron
Molecular Characterization
Clinical Isolate
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2013 Collection
 
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Citation counts: TR Web of Science Citation Count  Cited 20 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 26 times in Scopus Article | Citations
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Created: Mon, 21 May 2012, 22:44:47 EST by System User on behalf of UQ Centre for Clinical Research