Direct encapsulation of small molecule hydrophilic and hydrophobic actives in alginate microspheres using a novel impinging aerosols method

Sohail, A., Bhandari, B., Turner, M. S. and Coombes, A. G. A. (2012) Direct encapsulation of small molecule hydrophilic and hydrophobic actives in alginate microspheres using a novel impinging aerosols method. Journal of Drug Delivery Science and Technology, 22 2: 139-143.

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Name Description MIMEType Size Downloads
Author Sohail, A.
Bhandari, B.
Turner, M. S.
Coombes, A. G. A.
Title Direct encapsulation of small molecule hydrophilic and hydrophobic actives in alginate microspheres using a novel impinging aerosols method
Journal name Journal of Drug Delivery Science and Technology   Check publisher's open access policy
ISSN 1157-1489
1773-2247
Publication date 2012-03-01
Sub-type Article (original research)
Volume 22
Issue 2
Start page 139
End page 143
Total pages 5
Place of publication Paris, France
Publisher Editions de Sante
Collection year 2013
Language eng
Formatted abstract
The hydrophilic antibacterial (metronidazole, MZ) and a hydrophobic non-steroidal anti-inflammatory drug (ketoprofen, KET) were directly encapsulated in alginate microspheres (mean size < 40 μm), using the impinging aerosols method. Maximum ladings of 7 and 0.4 % were obtained for MZ and KET respectively with corresponding encapsulation efficiencies of 21 and 4 %. Around 75 and 96 % of the MZ content was released from hydrated and dried microspheres respectively in simulated gastric fluid within 20 min. Similarly, rapid release of 100 % of MZ occurred in SIF within 20 min for both hydrated and dried preparations but with retained anti-bacterial activity. Alginate microspheres encapsulating KET released less than 60 % of the drug in SGF within 2 h. Complete extraction of KET was obtained from hydrated microspheres in SIF in 2 h but was limited to around 70 % from dried samples; moreover KET release was sustained for 7 h. These findings demonstrate the utility of the impinging aerosols method for direct encapsulation of small molecule therapeutics, having a wide range of aqueous solubility in alginate microspheres.
Keyword Microencapsulation
Metronidazole
Ketoprofen
Drug release
Clostridium perfingens activity
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Agriculture and Food Sciences
Official 2013 Collection
School of Pharmacy Publications
 
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