Vasodilating versus first-generation β-blockers for cardiovascular protection

Fares, Hassan, Lavie, Carl J. and Ventura, Hector O. (2012) Vasodilating versus first-generation β-blockers for cardiovascular protection. Postgraduate Medicine, 124 2: 7-15. doi:10.3810/pgm.2012.03.2532

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Author Fares, Hassan
Lavie, Carl J.
Ventura, Hector O.
Title Vasodilating versus first-generation β-blockers for cardiovascular protection
Journal name Postgraduate Medicine   Check publisher's open access policy
ISSN 0032-5481
1941-9260
Publication date 2012-03
Sub-type Article (original research)
DOI 10.3810/pgm.2012.03.2532
Volume 124
Issue 2
Start page 7
End page 15
Total pages 9
Place of publication Berwyn, PA, United States
Publisher J T E Multimedia
Collection year 2013
Language eng
Abstract The utility of β-blockers in the treatment of hypertension has created much speculation as to their efficacy in patients with comorbid conditions, and there are concerns regarding their adverse metabolic effects. It is important to note that these findings were observed with traditional β-blockers, such as atenolol and metoprolol. The newer generation of β-blockers, namely carvedilol and nebivolol, is changing the manner in which β-blockers are viewed in hypertension management. Their ability to inhibit A1 adrenoreceptors and influence nitric oxide leads to vasodilation, which traditional β-blockers fail to do. These agents have been shown to have favorable metabolic effects while maintaining the beneficial cardiovascular effects of this drug class in post-myocardial infarction patients and the heart failure population.
Keyword Hypertension
Beta-blockers
Cardiovascular disease
Controlled-release carvedilol
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Medicine Publications
 
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Created: Mon, 21 May 2012, 22:05:55 EST by System User on behalf of School of Medicine