Variation in the XKR4 gene was significantly associated with subcutaneous rump fat thickness in indicine and composite cattle

Porto Neto, L. R., Bunch, R. J., Harrison, B. E. and Barendse, W. (2012) Variation in the XKR4 gene was significantly associated with subcutaneous rump fat thickness in indicine and composite cattle. Animal Genetics, : 1-5.


Author Porto Neto, L. R.
Bunch, R. J.
Harrison, B. E.
Barendse, W.
Title Variation in the XKR4 gene was significantly associated with subcutaneous rump fat thickness in indicine and composite cattle
Journal name Animal Genetics   Check publisher's open access policy
ISSN 0268-9146
1365-2052
Publication date 2012
Sub-type Article (original research)
DOI 10.1111/j.1365-2052.2012.02330.x
Start page 1
End page 5
Total pages 5
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell Publishing
Collection year 2013
Language eng
Abstract Variation in the XK, Kell blood group complex subunit-related family, member 4 (XKR4) gene on BTA14 was associated with rump fat thickness in a recent genome-wide association study. This region is also of interest because it is known to show evidence of a signature of population genetic selection. In this study, additional variation in this gene was genotyped in a sample of a total of 1283 animals of the Belmont Red (BEL) and Santa Gertrudis (SGT) breeds. The SNP rs41724387 was significantly (P < 0.001) associated with rump fat thickness and explained 5.9% of the genetic variance for the trait in this sample. Using the 4466 genotypes for the SNP rs42646708 from several data sets to estimate effects in seven breeds, this relatively large quantitative trait locus effect appears to be a result of the variation in indicine and taurine-indicine composite cattle. However, the only DNA variant found in Brahman cattle that altered the predicted amino acid sequence of XKR4 was not associated with rump fat thickness. This suggests that causative mutations lie outside the coding sequence of this gene.
Keyword BTA14
Cattle
DNA
Fat
Quantitative trait locus
Subcutaneous
XKR4
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ
Additional Notes Published online: 27 February 2012.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Veterinary Science Publications
 
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Created: Mon, 21 May 2012, 12:37:14 EST by Mr Laercio Porto-neto on behalf of School of Veterinary Science