Identification of molecular compartments and genetic circuitry in the developing mammalian kidney

Yu, Jing, Valerius, M. Todd, Duah, Mary, Staser, Karl, Hansard, Jennifer K., Guo, Jin-Jin, McMahon, Jill, Vaughan, Joe, Faria, Diane, Georgas, Kylie, Rumballe, Bree, Ren, Qun, Krautzberger, A. Michaela, Junker, Jan P., Thiagarajan, Rathi D., Machanick, Philip, Gray, Paul A., van Oudenaarden, Alexander, Rowitch, David H., Stiles, Charles D., Ma, Qiufu, Grimmond, Sean M., Bailey, Timothy L., Little, Melissa H. and McMahon, Andrew P. (2012) Identification of molecular compartments and genetic circuitry in the developing mammalian kidney. Development, 139 10: 1863-1873. doi:10.1242/dev.074005

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Author Yu, Jing
Valerius, M. Todd
Duah, Mary
Staser, Karl
Hansard, Jennifer K.
Guo, Jin-Jin
McMahon, Jill
Vaughan, Joe
Faria, Diane
Georgas, Kylie
Rumballe, Bree
Ren, Qun
Krautzberger, A. Michaela
Junker, Jan P.
Thiagarajan, Rathi D.
Machanick, Philip
Gray, Paul A.
van Oudenaarden, Alexander
Rowitch, David H.
Stiles, Charles D.
Ma, Qiufu
Grimmond, Sean M.
Bailey, Timothy L.
Little, Melissa H.
McMahon, Andrew P.
Title Identification of molecular compartments and genetic circuitry in the developing mammalian kidney
Journal name Development   Check publisher's open access policy
ISSN 0950-1991
Publication date 2012-05
Sub-type Article (original research)
DOI 10.1242/dev.074005
Open Access Status File (Publisher version)
Volume 139
Issue 10
Start page 1863
End page 1873
Total pages 11
Place of publication Cambridge, England, U.K.
Publisher The Company of Biologists
Collection year 2013
Language eng
Formatted abstract
Lengthy developmental programs generate cell diversity within an organotypic framework, enabling the later physiological actions of each organ system. Cell identity, cell diversity and cell function are determined by cell type-specific transcriptional programs; consequently, transcriptional regulatory factors are useful markers of emerging cellular complexity, and their expression patterns provide insights into the regulatory mechanisms at play. We performed a comprehensive genome-scale in situ expression screen of 921 transcriptional regulators in the developing mammalian urogenital system. Focusing on the kidney, analysis of regional-specific expression patterns identified novel markers and cell types associated with development and patterning of the urinary system. Furthermore, promoter analysis of synexpressed genes predicts transcriptional control mechanisms that regulate cell differentiation. The annotated informational resource ( will facilitate functional analysis of the mammalian kidney and provides useful information for the generation of novel genetic tools to manipulate emerging cell populations.
Keyword Genome-scale expression screen
Transcriptional regulator
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Accepted March 1, 2012.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
Institute for Molecular Bioscience - Publications
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