Identification of common variants associated with human hippocampal and intracranial volumes

Stein, Jason L., Medland, Sarah E., Vasquez, Alejandro Arias, Hibar, Derrek P., Senstad, Rudy E., Winkler, Anderson M., Toro, Roberto, Appel, Katja, Bartecek, Richard, Bergmann, Ørjan, Bernard, Manon, Brown, Andrew A., Cannon, Dara M., Chakravarty, M. Mallar, Christoforou, Andrea, Domin, Martin, Grimm, Oliver, Hollinshead, Marisa, Holmes, Avram J., Homuth, Georg, Hottenga, Jouke-Jan, Langan, Camilla, Lopez, Lorna M., Hansell, Narelle K., Hwang, Kristy S., Kim, Sungeun, Laje, Gonzalo, Lee, Phil H., Liu, Xinmin, Loth, Eva, Lourdusamy, Anbarasu, Mattingsdal, Morten, Mohnke, Sebastian, Maniega, Susana Muñoz, Nho, Kwangsik, Nugent, Allison C., O'Brien, Carol, Papmeyer, Martina, Pütz, Benno, Ramasamy, Adaikalavan, Rasmussen, Jerod, Rijpkema, Mark, Risacher, Shannon L., Roddey, J. Cooper, Rose, Emma J., Ryten, Mina, Shen, Li, Sprooten, Emma, Strengman, Eric, Teumer, Alexander, Trabzuni, Daniah, Turner, Jessica, van Eijk, Kristel, van Erp, Theo G. M., van Tol, Marie-Jose, Wittfeld, Katharina, Wolf, Christiane, Woudstra, Saskia, Aleman, Andre, Alhusaini, Saud, Almasy, Laura, Binder, Elisabeth B., Brohawn, David G., Cantor, Rita M., Carless, Melanie A., Corvin, Aiden, Czisch, Michael, Curran, Joanne E., Davies, Gail, de Almeida, Marcio A. A., Delanty, Norman, Depondt, Chantal, Duggirala, Ravi, Dyer, Thomas D., Erk, Susanne, Fagerness, Jesen, Fox, Peter T., Freimer, Nelson B., Gill, Michael, Göring, Harald H. H., Hagler, Donald J., Hoehn, David, Holsboer, Florian, Hoogman, Martine, Hosten, Norbert, Jahanshad, Neda, Johnson, Matthew P., Kasperaviciute, Dalia, Kent Jr., Jack W., Kochunov, Peter, Lancaster, Jack L., Lawrie, Stephen M., Liewald, David C., Mandl, René, Matarin, Mar, Mattheisen, Manuel, Meisenzahl, Eva, Melle, Ingrid, Moses, Eric K., Mühleisen, Thomas W., Nauck, Matthias, Nöthen, Markus M., Olvera, Rene L., Pandolfo, Massimo, Pike, G. Bruce, Puls, Ralf, Reinvang, Ivar, Rentería, Miguel E., Rietschel, Marcella, Roffman, Joshua L., Royle, Natalie A., Rujescu, Dan, Savitz, Jonathan, Schnack, Hugo G., Schnell, Knut, Seiferth, Nina, Smith, Colin, Steen, Vidar M., Hernández, Maria C. Valdés, Van den Heuvel, Martijn, van der Wee, Nic J., Van Haren, Neeltje E. M., Veltman, Joris A., Völzke, Henry, Walker, Robert, Westlye, Lars T., Whelan, Christopher D., Agartz, Ingrid, Boomsma, Dorret I., Cavalleri, Gianpiero L., Dale, Anders M., Djurovic, Srdjan, Drevets, Wayne C., Hagoort, Peter, Hall, Jeremy, Heinz, Andreas, Jack Jr., Clifford R., Foroud, Tatiana M, Le Hellard, Stephanie, Macciardi, Fabio, Montgomery, Grant W., Poline, Jean Baptiste, Porteous, David J., Sisodiya, Sanjay M., Starr, John M., Sussmann, Jessika, Toga, Arthur W., Veltman, Dick J., Walte, Henrik, Weiner, Michael W., the Alzheimer's Disease Neuroimaging Initiative (ADNI), EPIGEN Consortium, IMAGEN Consortium, Saguenay Youth Study Group (SYS), Bis, Joshua C., Ikram, M. Arfan, Smith, Albert V., Gudnason, Vilmundur, Tzourio, Christophe, Vernooij, Meike W, Launer, Lenore J., DeCarli, Charles, Seshadri, Sudha, Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, Andreassen, Ole A., Apostolova, Liana G., Bastin, Mark E., Blangero, John, Brunner, Han G., Buckner, Randy L., Cichon, Sven, Coppola, Giovanni, de Zubicaray, Greig I., Deary, Ian J., Donohoe, Gary, de Geus, Eco J. C., Espeseth, Thomas, Fernández, Guillén, Glahn, David C., Grabe, Hans J., Hardy, John, Pol, Hilleke E. Hulshoff, Jenkinson, Mark, Kahn, René S., McDonald, Colm, McIntosh, Andrew M., McMahon, Francis J., McMahon, Katie L., Meyer-Lindenberg, Andreas, Morris, Derek W., Müller-Myhsok, Bertram, Nichols, Thomas E., Ophoff, Roel A., Paus, Tomas, Pausova, Zdenka, Penninx, Brenda W., Potkin, Steven G., Sämann, Philipp G., Saykin, Andrew J., Schumann, Gunter, Smoller, Jordan W., Wardlaw, Joanna M., Weale, Michael E., Martin, Nicholas G., Franke, Barbara, Wright, Margaret J., Thompson, Paul M., for the Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Consortium, Danoy, Patrick and Brown, Matthew A. (2012) Identification of common variants associated with human hippocampal and intracranial volumes. Nature Genetics, 44 5: 552-561. doi:10.1038/ng.2250


Author Stein, Jason L.
Medland, Sarah E.
Vasquez, Alejandro Arias
Hibar, Derrek P.
Senstad, Rudy E.
Winkler, Anderson M.
Toro, Roberto
Appel, Katja
Bartecek, Richard
Bergmann, Ørjan
Bernard, Manon
Brown, Andrew A.
Cannon, Dara M.
Chakravarty, M. Mallar
Christoforou, Andrea
Domin, Martin
Grimm, Oliver
Hollinshead, Marisa
Holmes, Avram J.
Homuth, Georg
Hottenga, Jouke-Jan
Langan, Camilla
Lopez, Lorna M.
Hansell, Narelle K.
Hwang, Kristy S.
Kim, Sungeun
Laje, Gonzalo
Lee, Phil H.
Liu, Xinmin
Loth, Eva
Lourdusamy, Anbarasu
Mattingsdal, Morten
Mohnke, Sebastian
Maniega, Susana Muñoz
Nho, Kwangsik
Nugent, Allison C.
O'Brien, Carol
Papmeyer, Martina
Pütz, Benno
Ramasamy, Adaikalavan
Rasmussen, Jerod
Rijpkema, Mark
Risacher, Shannon L.
Roddey, J. Cooper
Rose, Emma J.
Ryten, Mina
Shen, Li
Sprooten, Emma
Strengman, Eric
Teumer, Alexander
Trabzuni, Daniah
Turner, Jessica
van Eijk, Kristel
van Erp, Theo G. M.
van Tol, Marie-Jose
Wittfeld, Katharina
Wolf, Christiane
Woudstra, Saskia
Aleman, Andre
Alhusaini, Saud
Almasy, Laura
Binder, Elisabeth B.
Brohawn, David G.
Cantor, Rita M.
Carless, Melanie A.
Corvin, Aiden
Czisch, Michael
Curran, Joanne E.
Davies, Gail
de Almeida, Marcio A. A.
Delanty, Norman
Depondt, Chantal
Duggirala, Ravi
Dyer, Thomas D.
Erk, Susanne
Fagerness, Jesen
Fox, Peter T.
Freimer, Nelson B.
Gill, Michael
Göring, Harald H. H.
Hagler, Donald J.
Hoehn, David
Holsboer, Florian
Hoogman, Martine
Hosten, Norbert
Jahanshad, Neda
Johnson, Matthew P.
Kasperaviciute, Dalia
Kent Jr., Jack W.
Kochunov, Peter
Lancaster, Jack L.
Lawrie, Stephen M.
Liewald, David C.
Mandl, René
Matarin, Mar
Mattheisen, Manuel
Meisenzahl, Eva
Melle, Ingrid
Moses, Eric K.
Mühleisen, Thomas W.
Nauck, Matthias
Nöthen, Markus M.
Olvera, Rene L.
Pandolfo, Massimo
Pike, G. Bruce
Puls, Ralf
Reinvang, Ivar
Rentería, Miguel E.
Rietschel, Marcella
Roffman, Joshua L.
Royle, Natalie A.
Rujescu, Dan
Savitz, Jonathan
Schnack, Hugo G.
Schnell, Knut
Seiferth, Nina
Smith, Colin
Steen, Vidar M.
Hernández, Maria C. Valdés
Van den Heuvel, Martijn
van der Wee, Nic J.
Van Haren, Neeltje E. M.
Veltman, Joris A.
Völzke, Henry
Walker, Robert
Westlye, Lars T.
Whelan, Christopher D.
Agartz, Ingrid
Boomsma, Dorret I.
Cavalleri, Gianpiero L.
Dale, Anders M.
Djurovic, Srdjan
Drevets, Wayne C.
Hagoort, Peter
Hall, Jeremy
Heinz, Andreas
Jack Jr., Clifford R.
Foroud, Tatiana M
Le Hellard, Stephanie
Macciardi, Fabio
Montgomery, Grant W.
Poline, Jean Baptiste
Porteous, David J.
Sisodiya, Sanjay M.
Starr, John M.
Sussmann, Jessika
Toga, Arthur W.
Veltman, Dick J.
Walte, Henrik
Weiner, Michael W.
the Alzheimer's Disease Neuroimaging Initiative (ADNI)
EPIGEN Consortium
IMAGEN Consortium
Saguenay Youth Study Group (SYS)
Bis, Joshua C.
Ikram, M. Arfan
Smith, Albert V.
Gudnason, Vilmundur
Tzourio, Christophe
Vernooij, Meike W
Launer, Lenore J.
DeCarli, Charles
Seshadri, Sudha
Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium
Andreassen, Ole A.
Apostolova, Liana G.
Bastin, Mark E.
Blangero, John
Brunner, Han G.
Buckner, Randy L.
Cichon, Sven
Coppola, Giovanni
de Zubicaray, Greig I.
Deary, Ian J.
Donohoe, Gary
de Geus, Eco J. C.
Espeseth, Thomas
Fernández, Guillén
Glahn, David C.
Grabe, Hans J.
Hardy, John
Pol, Hilleke E. Hulshoff
Jenkinson, Mark
Kahn, René S.
McDonald, Colm
McIntosh, Andrew M.
McMahon, Francis J.
McMahon, Katie L.
Meyer-Lindenberg, Andreas
Morris, Derek W.
Müller-Myhsok, Bertram
Nichols, Thomas E.
Ophoff, Roel A.
Paus, Tomas
Pausova, Zdenka
Penninx, Brenda W.
Potkin, Steven G.
Sämann, Philipp G.
Saykin, Andrew J.
Schumann, Gunter
Smoller, Jordan W.
Wardlaw, Joanna M.
Weale, Michael E.
Martin, Nicholas G.
Franke, Barbara
Wright, Margaret J.
Thompson, Paul M.
for the Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Consortium
Danoy, Patrick
Brown, Matthew A.
Total Author Count Override 316
Title Identification of common variants associated with human hippocampal and intracranial volumes
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1546-1718
1061-4036
Publication date 2012-05
Sub-type Article (original research)
DOI 10.1038/ng.2250
Volume 44
Issue 5
Start page 552
End page 561
Total pages 10
Place of publication New York, United States
Publisher Nature Group Publishing
Collection year 2013
Language eng
Formatted abstract
Identifying genetic variants influencing human brain structures may reveal new biological mechanisms underlying cognition and neuropsychiatric illness. The volume of the hippocampus is a biomarker of incipient Alzheimer’s disease1,2 and is reduced in schizophrenia3, major depression4 and mesial temporal lobe epilepsy5. Whereas many brain imaging phenotypes are highly heritable6,7, identifying and replicating genetic influences has been difficult, as small effects and the high costs of magnetic resonance imaging (MRI) have led to underpowered studies. Here we report genome-wide association meta-analyses and replication for mean bilateral hippocampal, total brain and intracranial volumes from a large multinational consortium. The intergenic variant rs7294919 was associated with hippocampal volume (12q24.22; N = 21,151; P = 6.70 × 10−16) and the expression levels of the positional candidate gene TESC in brain tissue. Additionally, rs10784502, located within HMGA2, was associated with intracranial volume (12q14.3; N = 15,782; P = 1.12 × 10−12). We also identified a suggestive association with total brain volume at rs10494373 within DDR2 (1q23.3; N = 6,500; P = 5.81 × 10−7).
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Thu, 17 May 2012, 10:19:22 EST by Sandrine Ducrot on behalf of School of Psychology