The use of an electrostatic lens to enhance the efficiency of the electrospinning process

Vaquette, Cédryck and Cooper-White, Justin (2012) The use of an electrostatic lens to enhance the efficiency of the electrospinning process. Cell and Tissue Research, 347 3: 815-826. doi:10.1007/s00441-011-1318-z


Author Vaquette, Cédryck
Cooper-White, Justin
Title The use of an electrostatic lens to enhance the efficiency of the electrospinning process
Journal name Cell and Tissue Research   Check publisher's open access policy
ISSN 0302-766X
1432-0878
Publication date 2012-03
Sub-type Article (original research)
DOI 10.1007/s00441-011-1318-z
Volume 347
Issue 3
Start page 815
End page 826
Total pages 12
Place of publication Heidelberg, Germany
Publisher Springer
Collection year 2013
Language eng
Abstract Electrospun scaffolds manufactured using conventional electrospinning configurations have an intrinsic thickness limitation, due to a charge build-up at the collector. To overcome this limitation, an electrostatic lens has been developed that, at the same relative rate of deposition, focuses the polymer jet onto a smaller area of the collector, resulting in the fabrication of thick scaffolds within a shorter period of time. We also observed that a longer deposition time (up to 13 h, without the intervention of the operator) could be achieved when the electrostatic lens was utilised, compared to 9-10 h with a conventional processing set-up and also showed that fibre fusion was less likely to occur in the modified method. This had a significant impact on the mechanical properties, as the scaffolds obtained with the conventional process had a higher elastic modulus and ultimate stress and strain at short times. However, as the thickness of the scaffolds produced by the conventional electrospinning process increased, a 3-fold decrease in the mechanical properties was observed. This was in contrast to the modified method, which showed a continual increase in mechanical properties, with the properties of the scaffold finally having similar mechanical properties to the scaffolds obtained via the conventional process at longer times. This "focusing" device thus enabled the fabrication of thicker 3-dimensional electrospun scaffolds (of thicknesses up to 3.5 mm), representing an important step towards the production of scaffolds for tissue engineering large defect sites in a multitude of tissues.
Keyword Polycaprolactone
Electrospinning
Tissue engineering
Electrostatic lens
Polymeric fibers
Cellular Infiltration
Polymer Fibers
Scaffolds
Jet
Nanofibers
Growth
Meshes
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online: 28 January 2012.

 
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Created: Mon, 14 May 2012, 22:08:58 EST by System User on behalf of Aust Institute for Bioengineering & Nanotechnology