Serum 25-hydroxyvitamin D levels in subjects with reduced glucose tolerance and type 2 diabetes - the Tromsø OGTT-Study

Hutchinson, Moira S., Figenschau, Yngve, Almas, Bjorg, Njolstad, Inger and Jorde, Rolf (2011) Serum 25-hydroxyvitamin D levels in subjects with reduced glucose tolerance and type 2 diabetes - the Tromsø OGTT-Study. International Journal for Vitamin and Nutrition Research, 81 5: 317-327. doi:10.1024/0300-9831/a000079

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Author Hutchinson, Moira S.
Figenschau, Yngve
Almas, Bjorg
Njolstad, Inger
Jorde, Rolf
Title Serum 25-hydroxyvitamin D levels in subjects with reduced glucose tolerance and type 2 diabetes - the Tromsø OGTT-Study
Journal name International Journal for Vitamin and Nutrition Research   Check publisher's open access policy
ISSN 0300-9831
1664-2821
Publication date 2011-09
Sub-type Article (original research)
DOI 10.1024/0300-9831/a000079
Volume 81
Issue 5
Start page 317
End page 327
Total pages 11
Place of publication Bern, Switzerland
Publisher Hans Huber
Collection year 2012
Language eng
Formatted abstract
The relationships between vitamin D concentrations, hyperglycemia, and insulin resistance remain uncertain. During 2008 - 2010, an oral glucose tolerance test was performed in 3520 subjects from Tromsø, Norway. Serum 25-hydroxyvitamin D [25(OH)D] was measured in 1193 subjects with normal glucose tolerance, in 304 with isolated impaired fasting glucose, in 254 with isolated impaired glucose tolerance, in 139 with a combination of the two, and in 194 subjects with type 2 diabetes. Serum 25(OH)D did not differ between subjects with isolated impaired fasting glucose or impaired glucose tolerance, but was lower in all groups of deranged glucose metabolism as compared with normal subjects. These differences could not be explained by differences in intakes of vitamin D from cod liver oil or other supplements and remained statistically significant after adjustment for gender, age, body mass index, physical activity score, and month of examination. When the cohort was divided according to serum 25(OH)D quartiles, there was an improvement in all measures of glucose metabolism (fasting and 2-hour plasma glucose, serum insulin, HbA1c) and estimates of insulin resistance (QUICKI , HOMA-IR, ISI0.120) with increasing serum 25(OH)D quartile. However, interventional studies are needed to prove a causal relationship between vitamin D and glucose metabolism.
Keyword Impaired fasting glucose
Impaired glucose tolerance
Insulin resistance
Type 2 diabetes
Vitamin D
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 11 times in Thomson Reuters Web of Science Article | Citations
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