Patterns of failure and treatment-related toxicity in advanced cervical cancer patients treated using extended field radiotherapy with curative intent

Rajasooriyar, Christhanthi, Van Dyk, Sylvia, Bernshaw, David, Kondalsamy-Chennakesavan, Srinivas, Barkati, Maroie and Narayan, Kailash (2011) Patterns of failure and treatment-related toxicity in advanced cervical cancer patients treated using extended field radiotherapy with curative intent. International Journal of Radiation Oncology Biology Physics, 80 2: 422-428. doi:10.1016/j.ijrobp.2010.02.026


Author Rajasooriyar, Christhanthi
Van Dyk, Sylvia
Bernshaw, David
Kondalsamy-Chennakesavan, Srinivas
Barkati, Maroie
Narayan, Kailash
Title Patterns of failure and treatment-related toxicity in advanced cervical cancer patients treated using extended field radiotherapy with curative intent
Journal name International Journal of Radiation Oncology Biology Physics   Check publisher's open access policy
ISSN 0360-3016
1879-355X
Publication date 2011-06-01
Year available 2010
Sub-type Article (original research)
DOI 10.1016/j.ijrobp.2010.02.026
Volume 80
Issue 2
Start page 422
End page 428
Total pages 7
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Collection year 2012
Language eng
Formatted abstract
Purpose

The purpose of this study was to evaluate the patterns of failure and overall survival (OS) and disease-free survival (DFS) rates in cervical cancer patients who had metastatic disease in common iliac or para-aortic lymph nodes and were treated with curative intent, using extended field radiotherapy (EFRT).

Methods and Materials

This was a retrospective study involving 39 patients treated from January 1996 to June 2007, using EFRT with concurrent chemotherapy and intracavitary brachytherapy. EFRT consisted of 45 Gy in 1.8-Gy fractions. Radiation to involved nodes was boosted to a total dose of 50.4 to 54 Gy. Primary tumor radiation was boosted to a dose of 80 Gy using brachytherapy.

Results


Overall, 30 patients (77%) have relapsed. The 5-year OS rate was 26% (95% confidence interval [CI], 11–44). The 5-year DFS rate was 19.4% (95% CI, 8–35). Only 3 patients (7.5%) experienced treatment failure exclusively within the treatment field, and 2 patients underwent salvage treatment. Grade 3 to 4 acute bone marrow and gastrointestinal toxicities were observed in 10 (26%) and 7 (18%) patients, respectively.

Conclusions


Concurrent chemotherapy and EFRT treatment was well tolerated. Most patients showed failure at multiple sites and outside the treatment field. Only 3/39 patients had failures exclusively within the treatment field, and 2 underwent salvage treatment.
Keyword Uterine cervical cancer
Extended field radiotherapy
Chemoradiation
Treatment outcome
Toxicity
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 22 May 2010.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Medicine Publications
 
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