Ellagic acid attenuates high-carbohydrate, high-fat diet-induced metabolic syndrome in rats

Panchal, Sunil K., Ward, Leigh and Brown, Lindsay (2013) Ellagic acid attenuates high-carbohydrate, high-fat diet-induced metabolic syndrome in rats. European Journal of Nutrition, 52 2: 559-568. doi:10.1007/s00394-012-0358-9

Author Panchal, Sunil K.
Ward, Leigh
Brown, Lindsay
Title Ellagic acid attenuates high-carbohydrate, high-fat diet-induced metabolic syndrome in rats
Journal name European Journal of Nutrition   Check publisher's open access policy
ISSN 1436-6207
Publication date 2013-03
Sub-type Article (original research)
DOI 10.1007/s00394-012-0358-9
Volume 52
Issue 2
Start page 559
End page 568
Total pages 10
Place of publication Heidelberg, Germany
Publisher Springer Medizin
Collection year 2013
Language eng
Formatted abstract
Background Fruits and nuts may prevent or reverse common human health conditions such as obesity, diabetes and hypertension; together, these conditions are referred to as metabolic syndrome, an increasing problem. This study has investigated the responses to ellagic acid, present in many fruits and nuts, in a diet-induced rat model of metabolic syndrome.
Methods Eight- to nine-week-old male Wistar rats were divided into four groups for 16-week feeding with cornstarch diet (C), cornstarch diet supplemented with ellagic acid (CE), high-carbohydrate, high-fat diet (H) and high-carbohydrate, high-fat diet supplemented with ellagic acid (HE). CE and HE rats were given 0.8 g/kg ellagic acid in food from week 8 to 16 only. At the end of 16 weeks, cardiovascular, hepatic and metabolic parameters along with protein levels of Nrf2, NF-κB and CPT1 in the heart and the liver were characterised.
Results High-carbohydrate, high-fat diet-fed rats developed cardiovascular remodelling, impaired ventricular function, impaired glucose tolerance, non-alcoholic fatty liver disease with increased protein levels of NF-κB and decreased protein levels of Nrf2 and CPT1 in the heart and the liver. Ellagic acid attenuated these diet-induced symptoms of metabolic syndrome with normalisation of protein levels of Nrf2, NF-κB and CPT1.
Conclusions Ellagic acid derived from nuts and fruits such as raspberries and pomegranates may provide a useful dietary supplement to decrease the characteristic changes in metabolism and in cardiac and hepatic structure and function induced by a high-carbohydrate, high-fat diet by suppressing oxidative stress and inflammation.
Keyword Cardiovascular remodelling
Ellagic acid
Metabolic syndrome
Non-alcoholic fatty liver disease
Cardiovascular disease
Liver disease
Oxidative Stress
Nonalcoholic steatohepatitis
Mechanistic clues
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online: 27 April 2012

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Biomedical Sciences Publications
School of Chemistry and Molecular Biosciences
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Citation counts: TR Web of Science Citation Count  Cited 30 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 01 May 2012, 15:09:56 EST by Lucy O'Brien on behalf of School of Chemistry & Molecular Biosciences