Regulation of the human plasminogen activator inhibitor type 2 gene COOPERATION OF AN UPSTREAM SILENCER AND TRANSACTIVATOR

Stringer, Brett, Udofa, Ekemini A. and Antalis, Toni M. (2012) Regulation of the human plasminogen activator inhibitor type 2 gene COOPERATION OF AN UPSTREAM SILENCER AND TRANSACTIVATOR. Journal of Biological Chemistry, 287 13: 10579-10589. doi:10.1074/jbc.M111.318758

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Author Stringer, Brett
Udofa, Ekemini A.
Antalis, Toni M.
Title Regulation of the human plasminogen activator inhibitor type 2 gene COOPERATION OF AN UPSTREAM SILENCER AND TRANSACTIVATOR
Journal name Journal of Biological Chemistry   Check publisher's open access policy
ISSN 0021-9258
1083-351X
Publication date 2012-03
Sub-type Article (original research)
DOI 10.1074/jbc.M111.318758
Open Access Status File (Publisher version)
Volume 287
Issue 13
Start page 10579
End page 10589
Total pages 11
Place of publication Bethesda, MD, United States
Publisher American Society for Biochemistry and Molecular Biology
Collection year 2013
Language eng
Formatted abstract
Background: PAI-2 (SERPINB2) is a serine protease inhibitor that is highly up-regulated in response to cellular stress.

Results: The upstream transactivator region of the SERPINB2 promoter was localized to an AP-1 site that overcomes PAUSE-1 silencer activity.

Conclusion: The AP-1 site binds factors that promote the derepression of the SERPINB2 promoter.

Significance: These data provide molecular insight into cell-specific derepression of the PAI-2 gene during cell differentiation and cancer.
Keyword Protein-kinase-C
Transcription factors
Cell-proliferation
Serpin superfamily
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Medicine Publications
 
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Created: Mon, 30 Apr 2012, 20:48:55 EST by System User on behalf of School of Medicine