Importance of T lymphocytes in brain injury, immunodeficiency, and recovery after cerebral ischemia

Brait, Vanessa H., Arumugam, Thiruma V., Drummond, Grant R. and Sobey, Christopher G. (2012) Importance of T lymphocytes in brain injury, immunodeficiency, and recovery after cerebral ischemia. Journal of Cerebral Blood Flow and Metabolism, 32 4: 598-611. doi:10.1038/jcbfm.2012.6


Author Brait, Vanessa H.
Arumugam, Thiruma V.
Drummond, Grant R.
Sobey, Christopher G.
Total Author Count Override 4
Title Importance of T lymphocytes in brain injury, immunodeficiency, and recovery after cerebral ischemia
Journal name Journal of Cerebral Blood Flow and Metabolism   Check publisher's open access policy
ISSN 0271-678X
1559-7016
Publication date 2012-04
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/jcbfm.2012.6
Volume 32
Issue 4
Start page 598
End page 611
Total pages 14
Place of publication New York, United States
Publisher Nature Publishing Group
Collection year 2013
Language eng
Abstract Following an ischemic stroke, T lymphocytes become activated, infiltrate the brain, and appear to release cytokines and reactive oxygen species to contribute to early inflammation and brain injury. However, some subsets of T lymphocytes may be beneficial even in the early stages after a stroke, and recent evidence suggests that T lymphocytes can also contribute to the repair and regeneration of the brain at later stages. In the hours to days after stroke, T-lymphocyte numbers are then reduced in the blood and in secondary lymphoid organs as part of a ‘stroke-induced immunodeficiency syndrome,’ which is mediated by hyperactivity of the sympathetic nervous system and the hypothalamic–pituitary–adrenal axis, resulting in increased risk of infectious complications. Whether or not poststroke T-lymphocyte activation occurs via an antigen-independent process, as opposed to a classical antigen-dependent process, is still controversial. Although considerable recent progress has been made, a better understanding of the roles of the different T-lymphocyte subpopulations and their temporal profile of damage versus repair will help to clarify whether T-lymphocyte targeting may be a viable poststroke therapy for clinical use.
Keyword Immune system
Ischemia
Neurogenesis
Reperfusion
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2013 Collection
School of Biomedical Sciences Publications
 
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