High density and high aspect ratio solid micro-nanoprojection arrays for targeted skin vaccine delivery and specific antibody extraction

Jenkins, Derek, Corrie, Simon, Flaim, Christopher and Kendall, Mark (2012) High density and high aspect ratio solid micro-nanoprojection arrays for targeted skin vaccine delivery and specific antibody extraction. RSC Advances, 2 8: 3490-3495. doi:10.1039/c2ra20153d

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Author Jenkins, Derek
Corrie, Simon
Flaim, Christopher
Kendall, Mark
Title High density and high aspect ratio solid micro-nanoprojection arrays for targeted skin vaccine delivery and specific antibody extraction
Journal name RSC Advances   Check publisher's open access policy
ISSN 2046-2069
Publication date 2012
Sub-type Article (original research)
DOI 10.1039/c2ra20153d
Open Access Status Not Open Access
Volume 2
Issue 8
Start page 3490
End page 3495
Total pages 6
Place of publication Cambridge, United Kingdom
Publisher Royal Society of Chemistry
Collection year 2013
Language eng
Formatted abstract
We introduce and describe a methodology for fabricating high-density and high aspect ratio micro-nanoprojection arrays—and further demonstrate the utility of these devices in targeting the skin for two different healthcare applications. The key to achieving the unprecedented high projection density (>20 000 cm−2) is the use of a controlled mixed plasma in a DRIE process, producing long, tapered tips without limiting the overall feature density. With a tailored process we produce structures of tuneable shape and height, with high uniformity across the face of silicon wafers. We show that these devices are suitable for both biological delivery and biomarker-specific extraction applications.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Citation counts: TR Web of Science Citation Count  Cited 21 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 30 Apr 2012, 20:19:59 EST by System User on behalf of Aust Institute for Bioengineering & Nanotechnology