Activity-dependent regulation of inhibitory synapse development by Npas4

Lin, Yingxi, Bloodgood, Brenda L., Hauser, Jessica L., Lapan, Ariya D., Koon, Alex C., Kim, Tae-Kyung, Hu, Linda S., Malik, Athar N. and Greenberg, Michael E. (2008) Activity-dependent regulation of inhibitory synapse development by Npas4. Nature, 455 7217: 1198-1204. doi:10.1038/nature07319

Author Lin, Yingxi
Bloodgood, Brenda L.
Hauser, Jessica L.
Lapan, Ariya D.
Koon, Alex C.
Kim, Tae-Kyung
Hu, Linda S.
Malik, Athar N.
Greenberg, Michael E.
Title Activity-dependent regulation of inhibitory synapse development by Npas4
Journal name Nature   Check publisher's open access policy
ISSN 0028-0836
Publication date 2008-10-30
Sub-type Article (original research)
DOI 10.1038/nature07319
Volume 455
Issue 7217
Start page 1198
End page 1204
Total pages 7
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Abstract Neuronal activity regulates the development and maturation of excitatory and inhibitory synapses in the mammalian brain. Several recent studies have identified signalling networks within neurons that control excitatory synapse development. However, less is known about the molecular mechanisms that regulate the activity-dependent development of GABA (γ-aminobutyric acid)-releasing inhibitory synapses. Here we report the identification of a transcription factor, Npas4, that plays a role in the development of inhibitory synapses by regulating the expression of activity-dependent genes, which in turn control the number of GABA-releasing synapses that form on excitatory neurons. These findings demonstrate that the activity-dependent gene program regulates inhibitory synapse development, and suggest a new role for this program in controlling the homeostatic balance between synaptic excitation and inhibition.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 204 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 30 Apr 2012, 15:34:06 EST by Susan Allen on behalf of Institute for Molecular Bioscience