Potential use of melatonin in sleep and delirium in the critically ill

Bellapart, J. and Boots, R. (2012) Potential use of melatonin in sleep and delirium in the critically ill. British Journal of Anaesthesia, 108 4: 572-580. doi:10.1093/bja/aes035

Author Bellapart, J.
Boots, R.
Title Potential use of melatonin in sleep and delirium in the critically ill
Journal name British Journal of Anaesthesia   Check publisher's open access policy
ISSN 0007-0912
Publication date 2012-04
Sub-type Article (original research)
DOI 10.1093/bja/aes035
Volume 108
Issue 4
Start page 572
End page 580
Total pages 9
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Collection year 2013
Language eng
Abstract Intensive care delirium is a well-recognized complication in critically ill patients. Delirium is an independent risk factor for death in the intensive care unit (ICU), leading to oversedation, increased duration of mechanical ventilation, and increased length of stay. Although there has not been a direct causal relationship shown between sleep deprivation and delirium, many studies have demonstrated that critically ill patients have an altered sleep pattern, abnormal levels of melatonin, and loss of circadian rhythms. Melatonin has a major role in control of circadian rhythm and sleep regulation and other effects on the immune system, neuroprotection, and oxidant/anti-oxidant activity. There has been interest in the use of exogenous melatonin as a measure to improve sleep. However, there are only a few studies of melatonin in ICU patients and these use heterogeneous methodologies. Therefore, it is not possible at this stage to make any clear recommendations regarding the clinical use of melatonin in this setting. There is a need for well-designed randomized controlled trials examining the role of melatonin in ICU.
Keyword Critical illness delirium
Sleep deprivation
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 26 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 23 Apr 2012, 22:08:15 EST by System User on behalf of Anaesthesiology and Critical Care - RBWH