Frequency and function of regulatory T cells after ischaemic stroke in humans

Yan, Jun, Read, Stephen J., Henderson, Robert D., Hull, Renee, O'Sullivan, John D., McCombe, Pamela A. and Greer, Judith M. (2012) Frequency and function of regulatory T cells after ischaemic stroke in humans. Journal of Neuroimmunology, 243 1-2: 89-94. doi:10.1016/j.jneuroim.2011.12.019

Author Yan, Jun
Read, Stephen J.
Henderson, Robert D.
Hull, Renee
O'Sullivan, John D.
McCombe, Pamela A.
Greer, Judith M.
Title Frequency and function of regulatory T cells after ischaemic stroke in humans
Journal name Journal of Neuroimmunology   Check publisher's open access policy
ISSN 0165-5728
Publication date 2012-02-29
Year available 2011
Sub-type Article (original research)
DOI 10.1016/j.jneuroim.2011.12.019
Volume 243
Issue 1-2
Start page 89
End page 94
Total pages 6
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Collection year 2013
Language eng
Abstract Ischaemic stroke is an important cause of disability and death. Local inflammation in the brain following stroke is thought to enhance damage. Animal studies show that regulatory T cells (Tregs) can downregulate this inflammation and assist recovery, but there are no previous studies of the function of Tregs in human stroke. The current study aimed to quantify Tregs in peripheral blood following stroke and to investigate their function. Treg numbers were significantly increased after stroke, particularly in males. However, the functional capacity of Tregs to inhibit proliferation of autologous cells at low ratios of Treg to responder cells was reduced, particularly in female patients, compared to controls. This study is the first to report gender-specific changes in the numbers and function of Tregs after ischaemic stroke. These changes may affect stroke outcome.
Keyword Foxp3
Acute ischaemic stroke
Regulatory T cells
Protective immunity
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes © 2011 Elsevier B.V. All rights reserved.

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2013 Collection
School of Medicine Publications
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