Caveolin-1, caveolae, and glioblastoma

Parat, Marie-Odile and Riggins, Gregory J. (2012) Caveolin-1, caveolae, and glioblastoma. Neuro-Oncology, 14 6: 679-688.


Author Parat, Marie-Odile
Riggins, Gregory J.
Total Author Count Override 2
Title Caveolin-1, caveolae, and glioblastoma
Journal name Neuro-Oncology   Check publisher's open access policy
ISSN 1522-8517
1523-5866
Publication date 2012-06
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1093/neuonc/nos079
Volume 14
Issue 6
Start page 679
End page 688
Total pages 10
Place of publication Cary, NC, United States
Publisher Oxford University Press
Collection year 2013
Language eng
Formatted abstract Glioblastoma multiforme (GBM) is the most common malignant brain tumor and is characterized by high invasiveness, poor prognosis, and limited therapeutic options. Biochemical and morphological experiments have shown the presence of caveolae in glioblastoma cells. Caveolae are flask-shaped plasma membrane subdomains that play trafficking, mechanosensing, and signaling roles. Caveolin-1 is a membrane protein that participates in the formation of caveolae and binds a multitude of signaling proteins, compartmentalizing them in caveolae and often directly regulating their activity via binding to its scaffolding domain. Caveolin-1 has been proposed to behave either as a tumor suppressor or as an ongogene depending on the tumor type and progress. This review discusses the existing information on the expression and function of caveolin-1 and caveolae in GBM and the role of this organelle and its defining protein on cellular signaling, growth, and invasiveness of GBM. We further analyze the available data suggesting caveolin-1 could be a target in GBM therapy.
Keyword Caveolae
Caveolin-1
EGF receptor
Glioblastoma
uPA
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes First published online: 16 April 2012.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2013 Collection
School of Pharmacy Publications
 
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Created: Mon, 23 Apr 2012, 14:57:15 EST by Myrtle Sahabandu on behalf of School of Pharmacy