Utility of positron emission tomography for the detection of disease in residual neck nodes after (chemo)radiotherapy in head and neck cancer

Porceddu, Sandro V., Jarmolowski, Elizabeth, Hicks, Rodney J., Ware, Rob, Weih, LeAnn, Rischin, Danny, Corry, June and Peters, Lester J. (2005) Utility of positron emission tomography for the detection of disease in residual neck nodes after (chemo)radiotherapy in head and neck cancer. Head and Neck, 27 3: 175-181. doi:10.1002/hed.20130


Author Porceddu, Sandro V.
Jarmolowski, Elizabeth
Hicks, Rodney J.
Ware, Rob
Weih, LeAnn
Rischin, Danny
Corry, June
Peters, Lester J.
Title Utility of positron emission tomography for the detection of disease in residual neck nodes after (chemo)radiotherapy in head and neck cancer
Journal name Head and Neck   Check publisher's open access policy
ISSN 1043-3074
1097-0347
Publication date 2005-03
Sub-type Article (original research)
DOI 10.1002/hed.20130
Volume 27
Issue 3
Start page 175
End page 181
Total pages 7
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Formatted abstract
Background: This study evaluates the utility of fluorine-18 fluorodeoxyglucose positron emission tomography (FDG PET) in patients with a node-positive mucosal head and neck squamous cell carcinoma who achieved a complete response at the primary site but had a residual mass in the neck 8 weeks or more after definitive (chemo)radiotherapy.

Methods: Between October 1996 and July 2002, 39 eligible patients were identified. The reference PET scan was performed at a median of 12 weeks (range, 8-32 weeks) after treatment.

Results: PET showed no metabolic activity in the residual mass in 32 patients. Five of these patients had a neck dissection and were all pathologically negative. The remaining 27 patients were observed for a median of 34 months (range, 16-86 months), with only one locoregional failure. The negative predictive value of PET for viable disease in a residual anatomic abnormality was 97%.

Conclusion: Patients who have achieved a complete response at the primary site but have a residual abnormality in the neck that is PET negative approximately 12 weeks after treatment do not require neck dissection and can be safely observed.
Keyword Chemotherapy
Head and neck
PET
Radiotherapy
Squamous cell cancer
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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