The 'QUAD SHOT' - a phase II study of palliative radiotherapy for incurable head and neck cancer

Corry, June, Peters, Lester J., D'Costa, Ieta, Milner, Alvin D., Fawns, Helen, Rischin, Danny and Porceddu, Sandro (2005) The 'QUAD SHOT' - a phase II study of palliative radiotherapy for incurable head and neck cancer. Radiotherapy and Oncology, 77 2: 137-142. doi:10.1016/j.radonc.2005.10.008

Author Corry, June
Peters, Lester J.
D'Costa, Ieta
Milner, Alvin D.
Fawns, Helen
Rischin, Danny
Porceddu, Sandro
Title The 'QUAD SHOT' - a phase II study of palliative radiotherapy for incurable head and neck cancer
Journal name Radiotherapy and Oncology   Check publisher's open access policy
ISSN 0167-8140
Publication date 2005-11
Sub-type Article (original research)
DOI 10.1016/j.radonc.2005.10.008
Volume 77
Issue 2
Start page 137
End page 142
Total pages 6
Place of publication Shannon, Co. Clare, Ireland
Publisher Elsevier
Language eng
Formatted abstract
Background and purpose: The primary objective of this study was to estimate the rate of tumour response to a cyclical hypofractionated palliative radiotherapy regimen (QUAD SHOT) in previously untreated patients with incurable squamous cell carcinoma of the head and neck. Secondary objectives were to prospectively evaluate toxicity, quality of life (QoL) and survival in these patients.

Patients and methods: The QUAD SHOT consisted of 14 Gy in four fractions, given twice a day and at least 6 h apart, for 2 consecutive days. This regimen was repeated at 4 weekly intervals for a further two courses if there was no tumour progression. The QoL tool used was an abbreviation of the EORTC QLQ-C30.

Results: Thirty eligible patients (29 Stage IV, 20 performance status 2-3) had at least one treatment and 16 patients completed all three cycles. Sixteen patients (53%) had an objective response (2CR, 14PR) and a further seven had stable disease. Median overall survival was 5.7 months, median progression free survival was 3.1 months. The treatment was very well tolerated, with improved QoL in 11 of 25 evaluable patients (44%).

Conclusion: The QUAD SHOT regimen is an effective palliative treatment with minimal toxicity and a good response rate, which impacts positively on patients' QoL.
Keyword Head and neck cancer
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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