T-cell receptor signaling and the pathogenesis of autoimmune arthritis: insights from mouse and man

Sakaguchi, Shimon, Benham, Helen, Cope, Andrew P. and Thomas, Ranjeny (2012) T-cell receptor signaling and the pathogenesis of autoimmune arthritis: insights from mouse and man. Immunology and Cell Biology, 90 3: 277-287. doi:10.1038/icb.2012.4


Author Sakaguchi, Shimon
Benham, Helen
Cope, Andrew P.
Thomas, Ranjeny
Title T-cell receptor signaling and the pathogenesis of autoimmune arthritis: insights from mouse and man
Journal name Immunology and Cell Biology   Check publisher's open access policy
ISSN 0818-9641
1440-1711
Publication date 2012-03
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/icb.2012.4
Volume 90
Issue 3
Start page 277
End page 287
Total pages 11
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2013
Language eng
Abstract The immune system has evolved to survey and respond appropriately to the universe of foreign pathogens, while at the same time deploying an intricate repertoire of mechanisms that keep responses to host tissues in check. For the adaptive immune system, specificity and sensitivity are provided by a large repertoire of antigen T-cell receptors (TCRs) constructed in their extracellular domain to recognize antigenic peptide fragments restricted and presented by histocompatibility complex molecules, and coupled through intracellular domains to signal transduction modules that serve to transmit environmental cues inside the cell. In this review we consider recent evidence that has provided insight into how altered TCR signaling thresholds could contribute to human autoimmune arthritis, including rheumatoid arthritis (RA), and the spondyloarthropathies (SpA). We also discuss mechanistic studies that demonstrate how perturbations of T-cell antigen receptor signaling in the SKG mouse model can promote systemic autoimmunity and the intersection with essential innate immune pathways that lead to the development of chronic inflammatory phenotypes.
Keyword Spondyloarthropathy
Rheumatoid arthritis
T-cell receptor
Innate immunity
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2013 Collection
UQ Diamantina Institute Publications
 
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