Crim1 has an essential role in glycogen trophoblast cell and sinusoidal-trophoblast giant cell development in the placenta

Pennisi, D. J., Kinna, G., Chiu, H. S., Simmons, D. G., Wilkinson, L. and Little, M. H. (2012) Crim1 has an essential role in glycogen trophoblast cell and sinusoidal-trophoblast giant cell development in the placenta. Placenta, 33 3: 175-182. doi:10.1016/j.placenta.2011.12.014


Author Pennisi, D. J.
Kinna, G.
Chiu, H. S.
Simmons, D. G.
Wilkinson, L.
Little, M. H.
Title Crim1 has an essential role in glycogen trophoblast cell and sinusoidal-trophoblast giant cell development in the placenta
Journal name Placenta   Check publisher's open access policy
ISSN 0143-4004
1532-3102
Publication date 2012-03
Sub-type Article (original research)
DOI 10.1016/j.placenta.2011.12.014
Volume 33
Issue 3
Start page 175
End page 182
Total pages 8
Place of publication Oxford, United Kingdom
Publisher Elsevier
Collection year 2013
Language eng
Formatted abstract
Normal placental development and function is essential for fetal growth of eutherian mammals. Mutational studies have shown that numerous growth factors are required for placental development and differentiation of placental lineages. Here, using a gene-trap mutant mouse line, Crim1KST264, we show that Crim1 is essential for murine placental development. Crim1 is a developmentally expressed, trans-membrane regulator of growth factor activity. Crim1KST264/KST264 mutant placentae displayed hypoplasia from 13.5 dpc, and altered structure from 15.5 dpc, including alterations in cell number in both the junctional and labyrinth zones. Using the reporter gene from the Crim1KST264 allele, we found that Crim1 is expressed in multiple cell types of the placenta, including strong expression in the spongiotrophoblast cells of the junctional zone. In the junctional zone of Crim1KST264/KST264 placentae, there was an increase in the glycogen trophoblast cells adjacent to the spongiotrophoblast cells. In the labyrinth zone, we found a decrease in the density of sinusoidal-trophoblast giant cells. Our findings show that Crim1 is required for placental development, and is necessary for the proper differentiation of sinusoidal-trophoblast giant cells and glycogen trophoblast cells.
Keyword Crim1
Spongiotrophoblast
Glycogen trophoblast cells
Lineage development
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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