A screen for genetic defects of the zebrafish ear

Schibler, Andria and Malicki, Jarema (2007) A screen for genetic defects of the zebrafish ear. Mechanisms of Development, 124 7-8: 592-604. doi:10.1016/j.mod.2007.04.005

Author Schibler, Andria
Malicki, Jarema
Title A screen for genetic defects of the zebrafish ear
Journal name Mechanisms of Development   Check publisher's open access policy
ISSN 0925-4773
Publication date 2007-08
Sub-type Article (original research)
DOI 10.1016/j.mod.2007.04.005
Volume 124
Issue 7-8
Start page 592
End page 604
Total pages 13
Place of publication Shannon, Co. Clare, Ireland
Publisher Elsevier
Language eng
Abstract To advance the understanding of genetic mechanisms involved in the patterning and the differentiation of the vertebrate auditory system, we screened for mutations affecting ear development in the zebrafish larva. Fifteen recessive mutant alleles have been isolated and analyzed. The phenotypes of these mutants involve abnormalities in ear morphology, otolith formation, or both processes in parallel. Among morphological defects, we found mutations affecting early patterning of the otic vesicle, the morphogenesis of semicircular canals, and the expansion of the ear lumen. The two most severe mutant phenotypes involve the absence of anterior and posterior cristae, as well as a severely misshapen morphology of the ear. In the category of otolith mutants, we found defects in otolith formation, growth, and shape. As it proved to be the case in past screening efforts of this type, these mutant lines represent an asset in the studies of molecular mechanisms that regulate vertebrate ear development.
Keyword Ear
Otic vesicle
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 12 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 12 times in Scopus Article | Citations
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