Methotrexate-associated mantle-cell lymphoma in an elderly man with myasthenia gravis

Tran, Huy, Cheung, Catherine, Gill, Devinder, Dua, Ujjwal, Nourse, Jamie, Boyle, Richard and Gandhi, Maher K. (2008) Methotrexate-associated mantle-cell lymphoma in an elderly man with myasthenia gravis. Nature Clinical Practice Oncology, 5 4: 234-238. doi:10.1038/ncponc1071


Author Tran, Huy
Cheung, Catherine
Gill, Devinder
Dua, Ujjwal
Nourse, Jamie
Boyle, Richard
Gandhi, Maher K.
Title Methotrexate-associated mantle-cell lymphoma in an elderly man with myasthenia gravis
Journal name Nature Clinical Practice Oncology   Check publisher's open access policy
ISSN 1743-4254
1743-4262
Publication date 2008-04
Sub-type Article (original research)
DOI 10.1038/ncponc1071
Volume 5
Issue 4
Start page 234
End page 238
Total pages 5
Place of publication London, United Kingdom
Publisher Nature
Language eng
Formatted abstract
Background: A 75-year-old man on methotrexate immunosuppression for myasthenia gravis presented with a 2-month history of lymphocytosis and bilateral inguinal adenopathy. There were no constitutional symptoms of fever, night sweats, or weight loss.

Investigations: Physical examination, blood tests, flow cytometry, fluorescent in situ hybridization, immunoglobulin gene sequencing, viral load quantification by real-time polymerase chain reaction, excisional lymph-node biopsy, bone-marrow biopsy, tumor morphology and immunohistochemistry, sequential CT and PET scans.

Diagnosis: Methotrexate-associated mantle-cell lymphoma. Management: Cessation of methotrexate, anthracycline-based combination chemo-immunotherapy, and maintenance rituximab.
Keyword Epstein-barr virus
Mantle-cell lymphoma
Methotrexate
Myasthenia gravis
Rituximab
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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