Dermatoscopy of facial actinic keratosis, intraepidermal carcinoma, and invasive squamous cell carcinoma: A progression model

Zalaudek, Iris, Giacomel, Jason, Schmid, Karin, Bondino, Silvia, Rosendahl, Cliff, Cavicchini, Stefano, Tourlaki, Athanasia, Gasparini, Saturnino, Bourne, Peter, Keir, Jeff, Kittler, Harald, Eibenschutz, Laura, Catricala, Caterina and Argenziano, Giuseppe (2012) Dermatoscopy of facial actinic keratosis, intraepidermal carcinoma, and invasive squamous cell carcinoma: A progression model. Journal of the American Academy of Dermatology, 66 4: 589-597. doi:10.1016/j.jaad.2011.02.011


Author Zalaudek, Iris
Giacomel, Jason
Schmid, Karin
Bondino, Silvia
Rosendahl, Cliff
Cavicchini, Stefano
Tourlaki, Athanasia
Gasparini, Saturnino
Bourne, Peter
Keir, Jeff
Kittler, Harald
Eibenschutz, Laura
Catricala, Caterina
Argenziano, Giuseppe
Title Dermatoscopy of facial actinic keratosis, intraepidermal carcinoma, and invasive squamous cell carcinoma: A progression model
Journal name Journal of the American Academy of Dermatology   Check publisher's open access policy
ISSN 0190-9622
1097-6787
Publication date 2012-04
Year available 2011
Sub-type Article (original research)
DOI 10.1016/j.jaad.2011.02.011
Volume 66
Issue 4
Start page 589
End page 597
Total pages 9
Place of publication Philadelphia, PA, United States
Publisher Mosby
Collection year 2013
Language eng
Formatted abstract
Background:
Little is known about the dermoscopic features of keratinocyte skin cancer. Objective: We sought to determine the dermoscopic features of facial actinic keratosis (AK), intraepidermal carcinoma (IEC), moderately to poorly differentiated invasive squamous cell carcinoma (SCC), and well-differentiated SCC of the keratoacanthoma type.

Methods:

This was a retrospective analysis of dermoscopic images of histopathologically diagnosed keratinocyte skin cancer.

Results:
A total of 243 (70 AK, 71 IEC, 78 SCC, and 24 keratoacanthomas) tumors of the face from 243 patients (mean age: 71.1 years; range: 44-94 years) were analyzed. The majority of patients had a fair skin type, history of melanoma or nonmelanoma skin cancer, and multiple AK. A red pseudonetwork was significantly associated with AK (P <.001), whereas dotted/glomerular vessels, diffuse yellow opaque scales, and microerosions were significantly more prevalent among IEC (P <.001). Hairpin vessels, linear-irregular vessels, targetoid hair follicles, white structureless areas, a central mass of keratin, and ulceration were significantly associated with invasive SCC (P <.001 for all criteria). Similar patterns as in SCC were observed among keratoacanthomas.

Limitations:
The retrospective design of our study and the lack of assessment of sensitivity and specificity of the dermoscopic criteria are limitations.

Conclusions:
Based on our findings we propose a progression model of facial AK developing into IEC and invasive SCC.
Keyword Actinic keratosis
Dermatoscopy
Nonmelanoma skin cancer
Squamous cell carcinoma
Nonpigmented Skin Tumors
Vascular Structures
Bowens-Disease
Dermoscopy
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 11 August 2011.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 48 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 69 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Mon, 09 Apr 2012, 11:55:15 EST by System User on behalf of School of Medicine