Transfer of gangliosides across the human placenta

Mitchell, M. D., Henare, K., Balakrishnan, B., Lowe, E., Fong, B. Y. and Mcjarrow, P. (2012) Transfer of gangliosides across the human placenta. Placenta, 33 4: 312-316. doi:10.1016/j.placenta.2011.12.018

Author Mitchell, M. D.
Henare, K.
Balakrishnan, B.
Lowe, E.
Fong, B. Y.
Mcjarrow, P.
Title Transfer of gangliosides across the human placenta
Journal name Placenta   Check publisher's open access policy
ISSN 0143-4004
Publication date 2012-04
Sub-type Article (original research)
DOI 10.1016/j.placenta.2011.12.018
Volume 33
Issue 4
Start page 312
End page 316
Total pages 5
Place of publication Oxford, United Kingdom
Publisher Elsevier
Collection year 2013
Language eng
Formatted abstract
Gangliosides are structural and functional glycosphingolipids, considered to have important roles in neuronal development in fetal and neonatal development and in memory formation. In this report, we have investigated the ability of bovine milk-derived gangliosides GM3 and GD3 to cross the human placenta.

Study design
We have employed the ex-vivo model of dually-perfused isolated human placental lobules.

There was significant uptake of both GD3 and GM3 from the maternal perfusate. There was significant increase of GM3 in the fetal side and a non-statistically significant trend for GD3 to increase on the fetal side.

Hence an apparent preference for GM3 release into fetal circulation. We suggest that gangliosides consumed by the mother enter her circulation, can be transferred across the placenta and may be available to the developing fetus for building neural connections.
Keyword Ganglioside
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2013 Collection
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Citation counts: TR Web of Science Citation Count  Cited 6 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 6 times in Scopus Article | Citations
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Created: Mon, 09 Apr 2012, 11:42:38 EST by System User on behalf of UQ Centre for Clinical Research