Natriuretic peptide drug leads from snake venom

Vink, S., Jin, A. H., Poth, K. J., Head, G. A. and Alewood, P. F. (2012) Natriuretic peptide drug leads from snake venom. Toxicon, 59 4: 434-445. doi:10.1016/j.toxicon.2010.12.001

Author Vink, S.
Jin, A. H.
Poth, K. J.
Head, G. A.
Alewood, P. F.
Title Natriuretic peptide drug leads from snake venom
Journal name Toxicon   Check publisher's open access policy
ISSN 0041-0101
Publication date 2012-03-15
Year available 2010
Sub-type Article (original research)
DOI 10.1016/j.toxicon.2010.12.001
Volume 59
Issue 4
Start page 434
End page 445
Total pages 12
Editor Reto Stöcklin
Alan Harvey
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon
Collection year 2013
Language eng
Formatted abstract
Natriuretic peptides are body fluid volume modulators, termed natriuretic peptides due to a role in natriuresis and diuresis. The three mammalian NPs, atrial natriuretic peptide (ANP), brain or b-type natriuretic peptide (BNP) and c-type natriuretic peptide (CNP), have been extensively investigated for their use as therapeutic agents for the treatment of cardiovascular diseases. Although effective, short half-lives and renal side effects limit their use. In approximately 30 years of research, NPs have been discovered in many vertebrates including mammals, amphibians, reptiles and fish, with plants and, more recently, bacteria also being found to possess NPs. Reptiles have produced some of the more interesting NPs, with dendroaspis natriuretic peptide (DNP), which was isolated from the venom of the green mamba (Dendroaspis angusticeps), having greater potency and increased stability as compared to the mammalian family members, and taipan natriuretic peptide c (TNPc), which was isolated from the venom of the inland taipan (Oxyuranus microlepidotus) displaying similar activity to ANP and DNP at rat natriuretic peptide receptor A. Although promising, more research is required in this field to develop therapeutics that overcome receptor-mediated clearance, and potential toxicity issues. This review investigates the use of snake venom NPs as therapeutic drug leads.
Keyword Natriuretic peptide
Guanylyl cyclase
Heart failure
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 10 December 2010. Special issue: From venoms to drugs.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
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