Diversity of emm sequence types in group A beta-haemolytic streptococci in two remote Northern Territory Indigenous communities: implications for vaccine development

Richardson, Leisha J., Towers, Rebecca J., Cheng, Allen C., Currie, Bart J., Carapetis, Jonathan R., Giffard, Phillip M. and McDonald, Malcolm I. (2010) Diversity of emm sequence types in group A beta-haemolytic streptococci in two remote Northern Territory Indigenous communities: implications for vaccine development. Vaccine, 28 32: 5301-5305. doi:10.1016/j.vaccine.2010.05.046


Author Richardson, Leisha J.
Towers, Rebecca J.
Cheng, Allen C.
Currie, Bart J.
Carapetis, Jonathan R.
Giffard, Phillip M.
McDonald, Malcolm I.
Title Diversity of emm sequence types in group A beta-haemolytic streptococci in two remote Northern Territory Indigenous communities: implications for vaccine development
Formatted title
Diversity of emm sequence types in group A beta-haemolytic streptococci in two remote Northern Territory Indigenous communities: implications for vaccine development
Journal name Vaccine   Check publisher's open access policy
ISSN 0264-410X
1873-2518
Publication date 2010-07-19
Sub-type Article (original research)
DOI 10.1016/j.vaccine.2010.05.046
Volume 28
Issue 32
Start page 5301
End page 5305
Total pages 5
Place of publication Oxford, United Kingdom
Publisher Elsevier
Language eng
Formatted abstract
There is a high burden of disease due to group A streptococcus (GAS) in remote Northern Territory (NT) Indigenous communities. A proposed 26-valent GAS M-type vaccine covers 80–90% of pharyngeal and invasive isolates in the US. We examined the diversity and distribution of emm types in two remote Indigenous communities in the NT Top End over a 17-year period and compared them to the proposed vaccine types. Eighty emm types were identified between 1991 and 2007. Diversity in both communities was high (overall Simpson's index 0.976), but varied between communities. Prior to 2004, 71 emm types were identified and an additional 9 emm types were identified during a period of active surveillance in 2004–2005. The proposed 26-valent vaccine would be expected to cover only 20% of emm types recovered in this study. Of the 80 emm types, 16 (20%) were new sequence types identified since the last assignment of M types in 2002. The diversity of streptococcal isolates was higher than that reported from most industrialized countries, and similar to that described in several developing countries. A vaccine based on such a variable antigen is unlikely to provide effective protection in the highest risk populations.
Keyword Streptococcus pyogenes
M-type vaccine
Australian Indigenous
emm typing
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 10 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 12 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 03 Apr 2012, 15:28:37 EST by System User on behalf of UQ Centre for Clinical Research